Staff – University of Copenhagen

Airway inflammation in chronic rhinosinusitis with nasal polyps and asthma: the united airways concept further supported

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Airway inflammation in chronic rhinosinusitis with nasal polyps and asthma : the united airways concept further supported. / Håkansson, Kåre; Bachert, Claus; Konge, Lars; Thomsen, Simon Francis; Pedersen, Anders Elm; Poulsen, Steen Seier; Martin-Bertelsen, Tomas; Winther, Ole; Backer, Vibeke; von Buchwald, Christian.

In: PloS one, Vol. 10, No. 7, e0127228, 2015.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Håkansson, K, Bachert, C, Konge, L, Thomsen, SF, Pedersen, AE, Poulsen, SS, Martin-Bertelsen, T, Winther, O, Backer, V & von Buchwald, C 2015, 'Airway inflammation in chronic rhinosinusitis with nasal polyps and asthma: the united airways concept further supported' PloS one, vol. 10, no. 7, e0127228. https://doi.org/10.1371/journal.pone.0127228

APA

Håkansson, K., Bachert, C., Konge, L., Thomsen, S. F., Pedersen, A. E., Poulsen, S. S., ... von Buchwald, C. (2015). Airway inflammation in chronic rhinosinusitis with nasal polyps and asthma: the united airways concept further supported. PloS one, 10(7), [e0127228]. https://doi.org/10.1371/journal.pone.0127228

Vancouver

Håkansson K, Bachert C, Konge L, Thomsen SF, Pedersen AE, Poulsen SS et al. Airway inflammation in chronic rhinosinusitis with nasal polyps and asthma: the united airways concept further supported. PloS one. 2015;10(7). e0127228. https://doi.org/10.1371/journal.pone.0127228

Author

Håkansson, Kåre ; Bachert, Claus ; Konge, Lars ; Thomsen, Simon Francis ; Pedersen, Anders Elm ; Poulsen, Steen Seier ; Martin-Bertelsen, Tomas ; Winther, Ole ; Backer, Vibeke ; von Buchwald, Christian. / Airway inflammation in chronic rhinosinusitis with nasal polyps and asthma : the united airways concept further supported. In: PloS one. 2015 ; Vol. 10, No. 7.

Bibtex

@article{2310002e3fbc49799edda3c6ce1e2672,
title = "Airway inflammation in chronic rhinosinusitis with nasal polyps and asthma: the united airways concept further supported",
abstract = "BACKGROUND: It has been established that patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have co-existing asthma.OBJECTIVE: We aimed to test two hypotheses: (i) upper and lower airway inflammation in CRSwNP is uniform in agreement with the united airways concept; and (ii) bronchial inflammation exists in all CRSwNP patients irrespective of clinical asthma status.METHODS: We collected biopsies from nasal polyps, inferior turbinates and bronchi of 27 CRSwNP patients and 6 controls. All participants were evaluated for lower airway disease according to international guidelines. Inflammatory cytokines were investigated using a Th1/Th2 assay including 14 chemokines and cytokines; tissue concentrations were normalized according to tissue weight and total protein concentration. Individual cytokines and multivariate inflammatory profiles were compared between biopsy sites and between patients and controls.RESULTS: We found significantly higher concentrations of Th2 cytokines in nasal polyps compared to inferior turbinate and bronchial biopsies. In addition, we showed that the inflammatory profile of nasal polyps and bronchial biopsies correlated significantly (p<0.01). From the Th2 cytokines measured, IL-13 was significantly increased in bronchial biopsies from CRSwNP patients with, but not without asthma.CONCLUSION: Our findings support the united airways concept; however, we did not find evidence for subclinical bronchial inflammation in CRSwNP patients without asthma. Finally, this study indicates for the first time that nasal polyps potentially play an important role in the airway inflammation rather than being a secondary phenomenon.",
author = "K{\aa}re H{\aa}kansson and Claus Bachert and Lars Konge and Thomsen, {Simon Francis} and Pedersen, {Anders Elm} and Poulsen, {Steen Seier} and Tomas Martin-Bertelsen and Ole Winther and Vibeke Backer and {von Buchwald}, Christian",
year = "2015",
doi = "10.1371/journal.pone.0127228",
language = "English",
volume = "10",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

RIS

TY - JOUR

T1 - Airway inflammation in chronic rhinosinusitis with nasal polyps and asthma

T2 - the united airways concept further supported

AU - Håkansson, Kåre

AU - Bachert, Claus

AU - Konge, Lars

AU - Thomsen, Simon Francis

AU - Pedersen, Anders Elm

AU - Poulsen, Steen Seier

AU - Martin-Bertelsen, Tomas

AU - Winther, Ole

AU - Backer, Vibeke

AU - von Buchwald, Christian

PY - 2015

Y1 - 2015

N2 - BACKGROUND: It has been established that patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have co-existing asthma.OBJECTIVE: We aimed to test two hypotheses: (i) upper and lower airway inflammation in CRSwNP is uniform in agreement with the united airways concept; and (ii) bronchial inflammation exists in all CRSwNP patients irrespective of clinical asthma status.METHODS: We collected biopsies from nasal polyps, inferior turbinates and bronchi of 27 CRSwNP patients and 6 controls. All participants were evaluated for lower airway disease according to international guidelines. Inflammatory cytokines were investigated using a Th1/Th2 assay including 14 chemokines and cytokines; tissue concentrations were normalized according to tissue weight and total protein concentration. Individual cytokines and multivariate inflammatory profiles were compared between biopsy sites and between patients and controls.RESULTS: We found significantly higher concentrations of Th2 cytokines in nasal polyps compared to inferior turbinate and bronchial biopsies. In addition, we showed that the inflammatory profile of nasal polyps and bronchial biopsies correlated significantly (p<0.01). From the Th2 cytokines measured, IL-13 was significantly increased in bronchial biopsies from CRSwNP patients with, but not without asthma.CONCLUSION: Our findings support the united airways concept; however, we did not find evidence for subclinical bronchial inflammation in CRSwNP patients without asthma. Finally, this study indicates for the first time that nasal polyps potentially play an important role in the airway inflammation rather than being a secondary phenomenon.

AB - BACKGROUND: It has been established that patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have co-existing asthma.OBJECTIVE: We aimed to test two hypotheses: (i) upper and lower airway inflammation in CRSwNP is uniform in agreement with the united airways concept; and (ii) bronchial inflammation exists in all CRSwNP patients irrespective of clinical asthma status.METHODS: We collected biopsies from nasal polyps, inferior turbinates and bronchi of 27 CRSwNP patients and 6 controls. All participants were evaluated for lower airway disease according to international guidelines. Inflammatory cytokines were investigated using a Th1/Th2 assay including 14 chemokines and cytokines; tissue concentrations were normalized according to tissue weight and total protein concentration. Individual cytokines and multivariate inflammatory profiles were compared between biopsy sites and between patients and controls.RESULTS: We found significantly higher concentrations of Th2 cytokines in nasal polyps compared to inferior turbinate and bronchial biopsies. In addition, we showed that the inflammatory profile of nasal polyps and bronchial biopsies correlated significantly (p<0.01). From the Th2 cytokines measured, IL-13 was significantly increased in bronchial biopsies from CRSwNP patients with, but not without asthma.CONCLUSION: Our findings support the united airways concept; however, we did not find evidence for subclinical bronchial inflammation in CRSwNP patients without asthma. Finally, this study indicates for the first time that nasal polyps potentially play an important role in the airway inflammation rather than being a secondary phenomenon.

U2 - 10.1371/journal.pone.0127228

DO - 10.1371/journal.pone.0127228

M3 - Journal article

VL - 10

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 7

M1 - e0127228

ER -

ID: 140763775