Claus Henrik Nielsen

Claus Henrik Nielsen

Professor

ORCID: 0000-0001-7543-9016

Publication year:
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  1. 2024
  2. E-pub ahead of print

    Suitability of machine learning models for prediction of clinically defined Stage III/IV periodontitis from questionnaires and demographic data in Danish cohorts

    Enevold, Christian, Nielsen, Claus Henrik, Christensen, Lisa Bøge, Kongstad, Johanne, Fiehn, Nils-Erik, Hansen, Peter Riis, Holmstrup, Palle, Havemose-Poulsen, A. & Damgaard, Christian, 2024, (E-pub ahead of print) In: Journal of Clinical Periodontology. 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2023
  4. Published

    B-cell cytokine responses to Porphyromonas gingivalis in patients with periodontitis and healthy controls

    Danielsen, Anne Katrine, Damgaard, Christian, Massarenti, Laura, Jensen, Peter Østrup, Hansen, Peter Riis, Holmstrup, Palle & Nielsen, Claus Henrik, 2023, In: Journal of Periodontology. 94, 8, p. 997-1007 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Blood Cell Biomarkers of Inflammation and Cytokine Levels as Predictors of Response to Biologics in Patients with Psoriasis

    Andersen, C. S. B., Kvist-Hansen, A., Siewertsen, M., Enevold, C., Hansen, Peter Riis, Knudsen, Diljit Kaur, Zachariae, Claus, Nielsen, Claus Henrik, Loft, N. & Skov, Lone, 2023, In: International Journal of Molecular Sciences. 24, 7, 15 p., 6111.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Cerebral abscesses with odontogenic origin: a population-based cohort study

    Jespersen, Frederik Viktor Bang, Hansen, S. U., Jensen, Simon Storgård, Omland, L. H., Helweg-Larsen, J., Bjarnsholt, Thomas, Nielsen, Claus Henrik, Ziebell, M., Bodilsen, J. & Markvart, Merete, 2023, In: Clinical Oral Investigations. 27, 7, p. 3639-364

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Characterization of circulating extracellular traps and immune responses to citrullinated LL37 in psoriasis

    Monreal, M. T. M., Kvist-Hansen, A., Massarenti, Laura, Steffensen, R., Loft, N., Hansen, Peter Riis, Ødum, Niels, Skov, Lone & Nielsen, Claus Henrik, 2023, In: Frontiers in Immunology. 14, 10 p., 1247592.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Characterization of patients with odontogenic necrotizing soft tissue infections in the head and neck area: A retrospective analysis

    Hansen, S. U., Jespersen, Frederik Viktor Bang, Markvart, Merete, Hyldegaard, Ole, Plaschke, Christina Caroline, Bjarnsholt, Thomas, Nielsen, Claus Henrik & Jensen, Simon Storgård, 2023, In: Acta Odontologica Scandinavica. 82, 1, p. 40-47

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Citrullination of myelin basic protein induces a Th17-cell response in healthy individuals and enhances the presentation of MBP85-99 in patients with multiple sclerosis

    Martín Monreal, M. T., Hansen, B. E., Iversen, P. F., Enevold, Christian, Ødum, Niels, Sellebjerg, Finn Thorup, Højrup, P., von Essen, Marina Rode & Nielsen, Claus Henrik, 2023, In: Journal of Autoimmunity. 139, 103092.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Interferon alpha-2 treatment reduces circulating neutrophil extracellular trap levels in myeloproliferative neoplasms

    Massarenti, Laura, Knudsen, T. A., Enevold, Christian, Skov, V., Kjær, L., Larsen, M. K., Larsen, T. S., Hansen, D. L., Hasselbalch, Hans Carl & Nielsen, Claus Henrik, 2023, In: British Journal of Haematology. 202, 2, p. 318-327 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Markers of neutrophil chemotaxis for identification of blood stream infections in children with acute lymphoblastic leukemia undergoing induction treatment

    Weischendorff, S., De Pietri, S., Rathe, M., Frandsen, T. L., Hasle, H., Nielsen, Claus Henrik, Moser, Claus Ernst & Muller, Klaus, 2023, In: European Journal of Haematology. 110, 6, p. 762-771

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Sjögren's syndrome: novel insights from proteomics and miRNA expression analysis

    Kamounah, Sarah, Sembler-Møller, Maria Lynn, Nielsen, Claus Henrik & Pedersen, Anne Marie Lynge, 2023, In: Frontiers in Immunology. 14, 21 p., 1183195.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Treated periodontitis and recurrent events after first-time myocardial infarction: A Danish nationwide cohort study

    Wagner, A. K., D'Souza, M., Bang, C. N., Holmstrup, Palle, Blanche, Paul Frédéric, Fiehn, Nils-Erik, Gislason, Gunnar Hilmar, Torp-Pedersen, Christian, Damgaard, Christian, Nielsen, Claus Henrik & Hansen, Peter Riis, 2023, In: Journal of Clinical Periodontology. 50, 10, p. 1305-1314 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. 2022
  15. Published

    Complement component 3 and its activation split-products in saliva associate with periodontitis

    Damgaard, Christian, Massarenti, Laura, Danielsen, Anne Katrine, Graversen, J. H., Holmstrup, Palle, Nielsen, Claus Henrik & Palarasah, Y., 2022, In: Journal of Periodontology. 93, 9, p. 1294-1301 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Influence of Insulin Receptor Single Nucleotide Polymorphisms on Glycaemic Control and Formation of Anti-Insulin Antibodies in Diabetes Mellitus

    Massarenti, Laura, Aniol-Nielsen, C., Enevold, C., Toft-Hansen, H. & Nielsen, Claus Henrik, 2022, In: International Journal of Molecular Sciences. 23, 12, 13 p., 6481.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis

    Massarenti, Laura, Enevold, C., Damgaard, D., Hansen, Peter Riis, Frisch, M., Ødum, Niels, Jacobsen, Søren & Nielsen, Claus Henrik, 2022, In: International Journal of Molecular Sciences. 23, 17, 10 p., 9536.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Severe weight loss in a hypothyroid patient as an acute presentation of autoimmune polyglandular syndrome type II

    Silajdzija, E., Bliddal, S., Borgwardt, L., Rossing, M., Jarløv, A., Nielsen, Claus Henrik & Feldt-Rasmussen, Ulla, 2022, In: Hormones. 21, 2, p. 317-322

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Thymic stromal lymphopoietin levels after allogeneic hematopoietic stem cell transplantation

    Møller, D. L., Kielsen, K., Nielsen, Claus Henrik, Sengeløv, Henrik, Pedersen, Anders Elm, Ryder, L. P. & Muller, Klaus, 2022, In: Immunopharmacology and Immunotoxicology. 44, 6, p. 1004-1012 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. 2021
  21. Published

    PADI4 Polymorphisms Confer Risk of Anti-CCP-Positive Rheumatoid Arthritis in Synergy With HLA-DRB1*04 and Smoking

    Massarenti, Laura, Enevold, C., Damgaard, D., Ødum, Niels, Garred, Peter, Frisch, M., Shelef, M. A., Jacobsen, Søren & Nielsen, Claus Henrik, 2021, In: Frontiers in Immunology. 12, 707690.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients

    Bliddal, S., Banasik, Karina, Pedersen, Ole Birger Vesterager, Nissen, J., Cantwell, Lisa, Schwinn, M., Tulstrup, Morten Rytter, Westergaard, David, Ullum, H., Brunak, Søren, Tommerup, Niels, Feenstra, B., Geller, F., Ostrowski, Sisse Rye, Grønbæk, Kirsten, Nielsen, Claus Henrik, Nielsen, Susanne Dam & Feldt-Rasmussen, Ulla, 2021, In: Scientific Reports. 11, 13153.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Applicability of Small-Molecule Inhibitors in the Study of Peptidyl Arginine Deiminase 2 (PAD2) and PAD4

    Martín Monreal, M. T., Stripp, Alexandra, Massarenti, Laura, Mondal, S., Šenolt, L., Ødum, Niels, Nielsen, Michael Lund, Thompson, P. R., Nielsen, Claus Henrik & Damgaard, D., 2021, In: Frontiers in Immunology. 12, 11 p., 716250.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    CDX2 regulates interleukin-33 gene expression in intestinal epithelial cells (LS174T)

    Larsen, S., Seidelin, Jakob Benedict, Davidsen, J., Dahlgaard, K., Nielsen, Claus Henrik, Bennett, Eric Paul, Pedersen, O. B., Coskun, M. & Troelsen, J. T., 2021, In: FEBS Open Bio. 11, 6, p. 1638-1644

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Circulating antibodies against leukotoxin A as marker of periodontitis grades B and C and oral infection with Aggregatibacter actinomycetemcomitans

    Damgaard, Christian, Danielsen, Anne Katrine, Enevold, C., Reinholdt, J., Holmstrup, Palle, Nielsen, Claus Henrik & Massarenti, Laura, 2021, In: Journal of Periodontology. 92, 12, p. 1795-1804 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Complement split product C3c in saliva as biomarker for periodontitis and response to periodontal treatment

    Suell, Maria Grande, Midjord-Belstrøm, Daniel, Damgaard, Christian, Holmstrup, Palle, Thangaraj, S. S., Nielsen, Claus Henrik & Palarasah, Y., 2021, In: Journal of Periodontal Research. 56, 1, p. 27-33 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Objective and noninvasive biochemical markers in rheumatoid arthritis: where are we and where are we going?

    Bay-Jensen, A. C., Siebuhr, A. S., Damgaard, D., Drobinski, P., Thudium, C., Mortensen, J. & Nielsen, Claus Henrik, 2021, In: Expert Review of Proteomics. 18, 3, p. 159-175 17 p.

    Research output: Contribution to journal › Review › Research › peer-review

  28. Published

    Periodontitis increases risk of viable bacteria in freshly drawn blood donations

    Damgaard, Christian, Sækmose, S. G., Nilsson, Carl Martin Peter, Kilian, Mogens, Nielsen, Claus Henrik & Holmstrup, Palle, 2021, In: Blood Transfusion. 19, 5, p. 376-383

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    The Extracellular Polysaccharide Matrix of Pseudomonas aeruginosa Biofilms Is a Determinant of Polymorphonuclear Leukocyte Responses

    Rybtke, Morten Levin, Jensen, Peter Østrup, Nielsen, Claus Henrik & Tolker-Nielsen, Tim, 2021, In: Infection and Immunity. 89, 1

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. 2020
  31. Published

    Identification of Novel Native Autoantigens in Rheumatoid Arthritis

    Poulsen, T. B. G., Damgaard, D., Jørgensen, M. M., Senolt, L., Blackburn, J. M., Nielsen, Claus Henrik & Stensballe, A., 2020, In: Biomedicines. 8, 6, 13 p., 141.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Ruxolitinib and interferon-alpha 2 combination therapy for patients with polycythemia vera or myelofibrosis: a phase II study

    Sorensen, A. L., Mikkelsen, Stine Ulrik, Knudsen, T. A., Bjorn, M. E., Andersen, Christen Bertel L, Bjerrum, O. W., Brochmann, N., Patel, D. A., Gjerdrum, Lise Mette Rahbek, El Fassi, D., Kruse, T. A., Larsen, T. S., Mourits-Andersen, H. T., Nielsen, Claus Henrik, Ellervik, Christina, Pallisgaard, N., Thomassen, M., Kjaer, L., Skov, V. & Hasselbach, H. C., 2020, In: Haematologica. 105, 9, p. 2262-2272 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. 2019
  34. Published

    Ruxolitinib treatment reduces monocytic superoxide radical formation without affecting hydrogen peroxide formation or systemic oxidative nucleoside damage in myelofibrosis

    Bjørn, M. E., Brimnes, M. K., Gudbrandsdottir, S., Andersen, C. L., Poulsen, Henrik Enghusen, Henriksen, T., Hasselbalch, Hans Carl & Nielsen, Claus Henrik, Oct 2019, In: Leukemia and Lymphoma. 60, 10, p. 2549-2557 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Porphyromonas gingivalis in saliva associates with chronic and aggressive periodontitis

    Damgaard, Christian, Danielsen, Anne Katrine, Enevold, C., Massarenti, Laura, Nielsen, Claus Henrik, Holmstrup, Palle & Midjord-Belstrøm, Daniel, 2019, In: Journal of Oral Microbiology. 11, 1, p. 1-9 9 p., 1653123.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Assessment of peptidylarginine deiminase activity by ELISA using human fibrinogen as substrate

    Damgaard, D. & Nielsen, Claus Henrik, 2019, Autoantibodies: Methods and Protocols. Houen, G. (ed.). Humana Press, p. 239-242 4 p. (Methods in Molecular Biology, Vol. 1901).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  37. Associations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifugation strategy

    Gejl, A. K., Enevold, C., Bugge, A., Andersen, M. S., Nielsen, Claus Henrik & Andersen, L. B., 2019, In: Scientific Reports. 9, 9 p., 9655.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Erythrocytes restrict microvesicle-induced production of reactive oxygen species by polymorphonuclear leukocytes

    Winberg, L. K., Rasmussen, N. S., Nielsen, Claus Henrik & Jacobsen, Søren, 2019, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 27, 7, p. 538-542 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Expanding the citrullinome of synovial fibrinogen from rheumatoid arthritis patients

    Sharma, M., Danigaard, D., Senolt, L., Svensson, B., Bay-Jensen, A., Nielsen, Claus Henrik & Hägglund, Per Mårten, 2019, In: Journal of Proteomics. 208, 103484.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Inflammatory functional iron deficiency common in myelofibrosis, contributes to anaemia and impairs quality of life. From the Nordic MPN study Group

    Birgegard, G., Samuelsson, J., Ahlstrand, E., Ejerblad, E., Enevold, C., Ghanima, W., Hasselbalch, Hans Carl, Nielsen, Claus Henrik, Knutsen, H., Pedersen, Ole Birger Vesterager, Sørensen, A. & Andreasson, B., 2019, In: European Journal of Haematology. 102, 3, p. 235-240

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Peptidylarginine deiminase-4 gene polymorphisms are associated with systemic lupus erythematosus and lupus nephritis

    Massarenti, Laura, Enevold, C., Damgaard, D., Ødum, Niels, Nielsen, Claus Henrik & Jacobsen, Søren, 2019, In: Scandinavian Journal of Rheumatology. 48, 2, p. 133-140

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Prognostic role of genetic polymorphisms of the interleukin-6 signaling pathway in patients with severe heart failure

    Hansen, Peter Riis, Nelveg-Kristensen, K. E., Rasmussen, H. B., Torp-Pedersen, C., Køber, Lars Valeur, Nielsen, Claus Henrik & Enevold, C., 2019, In: Pharmacogenomics Journal. 19, p. 428-437

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Release of active peptidylarginine deiminase into the circulation during acute inflammation induced by coronary artery bypass surgery

    Vejlstrup, A., Møller, A. M., Nielsen, Claus Henrik & Damgaard, D., 2019, In: Journal of Inflammation Research. 12, p. 137-144

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. 2018
  45. Published

    Safety and efficacy of combination therapy of interferon-α2 and ruxolitinib in polycythemia vera and myelofibrosis

    Mikkelsen, Stine Ulrik, Kjaer, L., Bjørn, M. E., Knudsen, T. A., Sørensen, A. L., Andersen, Christen Bertel L, Bjerrum, O. W., Brochmann, N., Fassi, Daniel El , Kruse, T. A., Larsen, T. S., Mourits-Andersen, H. T., Nielsen, Claus Henrik, Pallisgaard, N., Thomassen, M., Skov, V. & Hasselbalch, Hans Carl, Aug 2018, In: Cancer Medicine. 7, 8, p. 3571-3581 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Reconstitution of Th17, Tc17 and Treg cells after paediatric haematopoietic stem cell transplantation: Impact of interleukin-7

    Kielsen, K., Ryder, L. P., Lennox-Hvenekilde, D., Gad, M., Nielsen, Claus Henrik, Heilmann, C., Ifversen, M., Pedersen, Anders Elm & Muller, Klaus, Feb 2018, In: Immunobiology. 223, 2, p. 220-226 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3

    Damgaard, D., Bawadekar, M., Senolt, L., Stensballe, A., Shelef, M. A. & Nielsen, Claus Henrik, 2018, In: PLoS ONE. 13, 8, p. 1-14 e0203214.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Surfactant Protein D Deficiency Aggravates Cigarette Smoke-Induced Lung Inflammation by Upregulation of Ceramide Synthesis

    Pilecki, B., Wulf-Johansson, H., Støttrup, C., Jørgensen, P. T., Djiadeu, P., Nexøe, A. B., Schlosser, A., Hansen, S. W. K., Madsen, J., Clark, H. W., Nielsen, Claus Henrik, Vestbo, J., Palaniyar, N., Holmskov, U. & Sorensen, G. L., 2018, In: Frontiers in Immunology. 9, 12 p., 3013.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. 2017
  50. Published

    Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase

    Damgaard, D., Bjørn, M. E., Jensen, Peter Østrup & Nielsen, Claus Henrik, Dec 2017, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 32, 1, p. 1203-1208 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Microparticles from patients with systemic lupus erythematosus induce production of reactive oxygen species and degranulation of polymorphonuclear leukocytes

    Winberg, L. K., Jacobsen, Søren & Nielsen, Claus Henrik, 17 Oct 2017, In: Arthritis Research & Therapy. 19, 10 p., 230.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    The flame retardant DE-71 (a mixture of polybrominated diphenyl ethers) inhibits human differentiated thyroid cell function in vitro

    Kronborg, T. M., Hansen, J. F., Rasmussen, Å. K., Vorkamp, K., Nielsen, Claus Henrik, Frederiksen, M., Hofman-Bang, J., Hahn, Christoffer Holst, Ramhøj, L. & Feldt-Rasmussen, Ulla, Jun 2017, In: PloS one. 12, 6, 18 p., e0179858.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Cholesterol crystals enhance TLR2-and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis

    Køllgaard, T. M. S., Enevold, Christian, Bendtzen, K., Hansen, Peter Riis, Givskov, Michael, Holmstrup, Palle & Nielsen, Claus Henrik, 24 Feb 2017, In: P L o S One. 12, 2, 14 p., 0172773.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician

    Holmstrup, Palle, Damgaard, Christian, Olsen, I., Klinge, B., Flyvbjerg, A., Nielsen, Claus Henrik & Hansen, Peter Riis, 2017, In: Journal of Oral Microbiology. 9, 1, 14 p., 1332710.

    Research output: Contribution to journal › Review › Research › peer-review

  55. Published

    Immunoglobulin G antibodies against Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans in cardiovascular disease and periodontitis

    Damgaard, Christian, Reinholdt, J., Enevold, C., Fiehn, Nils-Erik, Nielsen, Claus Henrik & Holmstrup, Palle, 2017, In: Journal of Oral Microbiology. 9, 1, 1374154.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    In vitro complement activation, adherence to red blood cells and induction of mononuclear cell cytokine production by four strains of Aggregatibacter actinomycetemcomitans with different fimbriation and expression of leukotoxin

    Damgaard, Christian, Reinholdt, J., Palarasah, Y., Enevold, Christian, Nielsen, C., Brimnes, M. K., Holmstrup, Palle & Nielsen, Claus Henrik, 2017, In: Journal of Periodontal Research. 52, 3, p. 485-496 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Komorbiditet ved marginal parodontitis: To sider af samme sag?

    Holmstrup, Palle, Damgaard, Christian, Olsen, I., Klinge, B., Flyvbjerg, A., Nielsen, Claus Henrik & Hansen, Peter Riis, 2017, In: Tandlaegebladet. 121, 1, p. 52-61

    Research output: Contribution to journal › Review › Research › peer-review

  58. Published

    Porphyromonas gingivalis-induced production of reactive oxygen species, tumor necrosis factor-α, interleukin-6, CXCL8 and CCL2 by neutrophils from localized aggressive periodontitis and healthy donors: modulating actions of red blood cells and resolvin E1

    Damgaard, Christian, Kantarci, A., Holmstrup, Palle, Hasturk, H., Nielsen, Claus Henrik & Van Dyke, T. E., 2017, In: Journal of Periodontal Research. 52, 2, p. 246-254 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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