Can alterations in integrin and laminin-5 expression be used as markers of malignancy?

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Standard

Can alterations in integrin and laminin-5 expression be used as markers of malignancy? / Thorup, A K; Reibel, J; Schiødt, M; Stenersen, T C; Therkildsen, M H; Carter, W G; Dabelsteen, Erik.

In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 106, No. 12, 12.1998, p. 1170-80.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Thorup, AK, Reibel, J, Schiødt, M, Stenersen, TC, Therkildsen, MH, Carter, WG & Dabelsteen, E 1998, 'Can alterations in integrin and laminin-5 expression be used as markers of malignancy?', APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, vol. 106, no. 12, pp. 1170-80.

APA

Thorup, A. K., Reibel, J., Schiødt, M., Stenersen, T. C., Therkildsen, M. H., Carter, W. G., & Dabelsteen, E. (1998). Can alterations in integrin and laminin-5 expression be used as markers of malignancy? APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 106(12), 1170-80.

Vancouver

Thorup AK, Reibel J, Schiødt M, Stenersen TC, Therkildsen MH, Carter WG et al. Can alterations in integrin and laminin-5 expression be used as markers of malignancy? APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 1998 Dec;106(12):1170-80.

Author

Thorup, A K ; Reibel, J ; Schiødt, M ; Stenersen, T C ; Therkildsen, M H ; Carter, W G ; Dabelsteen, Erik. / Can alterations in integrin and laminin-5 expression be used as markers of malignancy?. In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 1998 ; Vol. 106, No. 12. pp. 1170-80.

Bibtex

@article{8df52a98578b49dea9a5a1aa5dbeb49a,
title = "Can alterations in integrin and laminin-5 expression be used as markers of malignancy?",
abstract = "Development of squamous cell carcinomas (SCCs) involves alterations in the adhesive interactions in the epithelium and invasion through the basement membrane. Therefore, changes in the expression of receptors and ligands involved in cell-cell and cell-matrix adhesion may be essential for the transformation of a premalignant into a malignant lesion. The aim of this study was to examine if expression of specific cell adhesion molecules can be used as markers of malignant development. By immunohistochemistry, we examined the expression pattern of integrins alpha2beta1, alpha3beta1, alpha6beta4 and laminin-5 in biopsies from SCCs (n=18), premalignant lesions (leukoplakias, n=21) and non-premalignant tissue with chronic inflammation (n=11). In poorly differentiated SCCs, patchy loss of alpha3beta1, alpha6beta4 and laminin-5 expression was pronounced at the invasion front, whereas there was a tendency to increased expression of alpha2beta1. Analogous to the SCCs, biopsies from the leukoplakias and the non-premalignant inflammatory tissue showed alterations of the expression of alpha3beta1 and alpha6beta4 in the basal cell layers and of laminin-5. However, a characteristic finding in biopsies from leukoplakias was loss of alpha2beta1 and alpha3beta1 in the suprabasal cells. There was no unequivocal expression of the adhesion molecules distinguishing between inflammatory tissue, premalignant, and malignant lesions.",
keywords = "Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell, Cell Adhesion Molecules, Humans, Integrins, Leukoplakia, Oral, Middle Aged, Precancerous Conditions, Tumor Markers, Biological",
author = "Thorup, {A K} and J Reibel and M Schi{\o}dt and Stenersen, {T C} and Therkildsen, {M H} and Carter, {W G} and Erik Dabelsteen",
year = "1998",
month = dec,
language = "English",
volume = "106",
pages = "1170--80",
journal = "A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica",
issn = "0903-4641",
publisher = "Wiley Online",
number = "12",

}

RIS

TY - JOUR

T1 - Can alterations in integrin and laminin-5 expression be used as markers of malignancy?

AU - Thorup, A K

AU - Reibel, J

AU - Schiødt, M

AU - Stenersen, T C

AU - Therkildsen, M H

AU - Carter, W G

AU - Dabelsteen, Erik

PY - 1998/12

Y1 - 1998/12

N2 - Development of squamous cell carcinomas (SCCs) involves alterations in the adhesive interactions in the epithelium and invasion through the basement membrane. Therefore, changes in the expression of receptors and ligands involved in cell-cell and cell-matrix adhesion may be essential for the transformation of a premalignant into a malignant lesion. The aim of this study was to examine if expression of specific cell adhesion molecules can be used as markers of malignant development. By immunohistochemistry, we examined the expression pattern of integrins alpha2beta1, alpha3beta1, alpha6beta4 and laminin-5 in biopsies from SCCs (n=18), premalignant lesions (leukoplakias, n=21) and non-premalignant tissue with chronic inflammation (n=11). In poorly differentiated SCCs, patchy loss of alpha3beta1, alpha6beta4 and laminin-5 expression was pronounced at the invasion front, whereas there was a tendency to increased expression of alpha2beta1. Analogous to the SCCs, biopsies from the leukoplakias and the non-premalignant inflammatory tissue showed alterations of the expression of alpha3beta1 and alpha6beta4 in the basal cell layers and of laminin-5. However, a characteristic finding in biopsies from leukoplakias was loss of alpha2beta1 and alpha3beta1 in the suprabasal cells. There was no unequivocal expression of the adhesion molecules distinguishing between inflammatory tissue, premalignant, and malignant lesions.

AB - Development of squamous cell carcinomas (SCCs) involves alterations in the adhesive interactions in the epithelium and invasion through the basement membrane. Therefore, changes in the expression of receptors and ligands involved in cell-cell and cell-matrix adhesion may be essential for the transformation of a premalignant into a malignant lesion. The aim of this study was to examine if expression of specific cell adhesion molecules can be used as markers of malignant development. By immunohistochemistry, we examined the expression pattern of integrins alpha2beta1, alpha3beta1, alpha6beta4 and laminin-5 in biopsies from SCCs (n=18), premalignant lesions (leukoplakias, n=21) and non-premalignant tissue with chronic inflammation (n=11). In poorly differentiated SCCs, patchy loss of alpha3beta1, alpha6beta4 and laminin-5 expression was pronounced at the invasion front, whereas there was a tendency to increased expression of alpha2beta1. Analogous to the SCCs, biopsies from the leukoplakias and the non-premalignant inflammatory tissue showed alterations of the expression of alpha3beta1 and alpha6beta4 in the basal cell layers and of laminin-5. However, a characteristic finding in biopsies from leukoplakias was loss of alpha2beta1 and alpha3beta1 in the suprabasal cells. There was no unequivocal expression of the adhesion molecules distinguishing between inflammatory tissue, premalignant, and malignant lesions.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Carcinoma, Squamous Cell

KW - Cell Adhesion Molecules

KW - Humans

KW - Integrins

KW - Leukoplakia, Oral

KW - Middle Aged

KW - Precancerous Conditions

KW - Tumor Markers, Biological

M3 - Journal article

C2 - 10052726

VL - 106

SP - 1170

EP - 1180

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 12

ER -

ID: 119593729