Can the genotype or phenotype of two polymorphic drug metabolising cytochrome P450-enzymes identify oral lichenoid drug eruptions?
Research output: Contribution to journal › Journal article › Research › peer-review
Lichenoid drug eruptions (LDE) in the oral cavity are adverse drug reactions (ADR) that are impossible to differentiate from oral lichen planus (OLP) as no phenotypic criteria exist. Impaired function of polymorphic cytochrome 450-enzymes (CYPs) may cause increased plasma concentration of some drugs resulting in ADR/LDE. In an earlier study we did not find more patients with OLP (OLPs) with impaired CYP-genotype.
| Original language | English |
|---|---|
| Journal | Journal of Oral Pathology & Medicine |
| Volume | 39 |
| Issue number | 6 |
| Pages (from-to) | 497-505 |
| Number of pages | 9 |
| ISSN | 0904-2512 |
| DOIs | |
| Publication status | Published - Jul 2010 |
- Adult, Aged, Aged, 80 and over, Alleles, Aryl Hydrocarbon Hydroxylases, Chi-Square Distribution, Cytochrome P-450 CYP2D6, Diagnosis, Differential, Drug Interactions, Female, Genotype, Humans, Lichen Planus, Oral, Male, Mephenytoin, Middle Aged, Phenotype, Polymorphism, Genetic, Polypharmacy, Questionnaires, Sparteine, Statistics, Nonparametric
Research areas
ID: 21454348