Claus Henrik Nielsen
Professor
Section 03 - Radiology
Nørre Allé 20
2200 København N
- 2010
- Published
Monozygotic twin pairs discordant for Hashimoto's thyroiditis share a high proportion of thyroid peroxidase autoantibodies to the immunodominant region A. Further evidence for genetic transmission of epitopic “fingerprints”
Brix, T. H., Hegedüs, L., Gardas, A., Banga, J. P. & Nielsen, Claus Henrik, 1 Oct 2010, In: Autoimmunity.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vitro cytokine responses to periodontal pathogens: generalized aggressive periodontitis is associated with increased IL-6 response to Porphyromonas gingivalis
Borch, T. S., Holmstrup, P., Bendtzen, K. & Nielsen, Claus Henrik, 1 Jun 2010, In: Scandinavian Journal of Immunology. 71, 6, p. 440-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell saver for on-pump coronary operations reduces systemic inflammatory markers: a randomized trial
Damgaard, Sune, Nielsen, Claus Henrik, Andersen, L. W., Bendtzen, K., Tvede, M. & Steinbrüchel, D., 1 May 2010, In: Annals of Thoracic Surgery. 89, 5, p. 1511-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The self-antigen, thyroglobulin, induces antigen-experienced CD4+ T cells from healthy donors to proliferate and promote production of the regulatory cytokine, interleukin-10, by monocytes
Nielsen, Claus Henrik, Galdiers, M. P., Hedegaard, C. J. & Leslie, R. G. Q., 1 Feb 2010, In: Immunology. 129, 2, p. 291-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Evidence of orbital B and T cell depletion after rituximab therapy in Graves' ophthalmopathy
Nielsen, J. F., El Fassi, D., Nielsen, Claus Henrik, Hegedüs, L., Lauer, S. A., Silkiss, R. Z., Prause, J. U., Nielsen, J. F., Fassi, Daniel El , Nielsen, C. H., Hegedüs, L., Lauer, S. A., Silkiss, R. Z. & Prause, J. U., 1 Nov 2009, In: Acta Ophthamologica (Online). 87, 8, p. 927-9 3 p.Research output: Contribution to journal › Journal article › Research
- Published
Biomimetic triblock copolymer membrane arrays: A stable template for functional membrane proteins
Gonzalez-Perez, Alfredo, Stibius, K. B., Vissing, T., Nielsen, Claus Henrik & Mouritsen, Ole G., 15 Sep 2009, In: Langmuir. 25, 18, p. 10447-10450 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Autoantibodies to myelin basic protein (MBP) in healthy individuals and in patients with multiple sclerosis: a role in regulating cytokine responses to MBP
Hedegaard, C. J., Chen, N., Sellebjerg, Finn Thorup, Sørensen, Per Soelberg, Leslie, R. G. Q., Bendtzen, K. & Nielsen, Claus Henrik, 1 Sep 2009, In: Immunology. 128, 1 Suppl, p. e451-61Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A role for autoantibodies in enhancement of pro-inflammatory cytokine responses to a self-antigen, thyroid peroxidase
Nielsen, Claus Henrik, Brix, T. H., Leslie, R. G. Q. & Hegedüs, L., 2009, In: Clinical Immunology. 133, 2, p. 218-27 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Decreased interleukin-2 responses to Fusobacterium nucleatum and Porphyromonas gingivalis in generalized aggressive periodontitis
Borch, T. S., Løbner, M., Bendtzen, K., Holmstrup, Palle & Nielsen, Claus Henrik, 2009, In: Journal of Periodontology. 80, 5, p. 800-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Spontaneous complement activation on human B cells results in localized membrane depolarization and the clustering of complement receptor type 2 and C3 fragments
Løbner, M., Leslie, R. G. Q., Prodinger, W. M. & Nielsen, Claus Henrik, 2009, In: Immunology. 128, 1 Suppl, p. e661-9Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Epitope recognition patterns of thyroid peroxidase autoantibodies in healthy individuals and patients with Hashimoto's thyroiditis*
Nielsen, Claus Henrik, Brix, T. H., Gardas, A., Banga, J. P. & Hegedüs, L., 1 Oct 2008, In: Clinical Endocrinology. 69, 4, p. 664-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis
Hedegaard, C. J., Krakauer, M., Bendtzen, K., Lund, H., Sellebjerg, Finn Thorup & Nielsen, Claus Henrik, 1 Oct 2008, In: Immunology. 125, 2, p. 161-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis
Hedegaard, C. J., Krakauer, M., Bendtzen, K., Sørensen, Per Soelberg, Sellebjerg, Finn Thorup & Nielsen, Claus Henrik, 1 Oct 2008, In: Clinical Immunology. 129, 1, p. 80-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Application of new therapies in Graves' disease and thyroid-associated ophthalmopathy: animal models and translation to human clinical trials
Banga, J. P., Nielsen, Claus Henrik, Gilbert, J. A., Fassi, Daniel El & Hegedus, L., 1 Sep 2008, In: Thyroid. 18, 9, p. 973-81 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biologiske behandlingsmuligheder ved Graves' oftalmopati
Fassi, Daniel El , Nielsen, Claus Henrik & Hegedüs, L., 9 Jun 2008, In: Ugeskrift for Laeger. 170, 24, p. 2128-30 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nye behandlinger af Graves' sygdom med fokus på det B-lymfocyt-depleterende antistof rituximab
Nielsen, Claus Henrik, Fassi, Daniel El & Hegedüs, L., 9 Jun 2008, In: Ugeskrift for Laeger. 170, 24, p. 2131-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enhancement of human adaptive immune responses by administration of a high-molecular-weight polysaccharide extract from the cyanobacterium Arthrospira platensis
Løbner, M., Walsted, A., Larsen, R., Bendtzen, K. & Nielsen, Claus Henrik, 1 Jun 2008, In: Journal of Medicinal Food. 11, 2, p. 313-22 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ulcerative colitis following B lymphocyte depletion with rituximab in a patient with Graves' disease
Fassi, Daniel El , Nielsen, Claus Henrik, Kjeldsen, J. B., Clemmensen, O. & Hegedüs, L., 1 May 2008, In: Gut. 57, 5, p. 714-5 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reduced folate carrier polymorphism determines methotrexate uptake by B cells and CD4+ T cells
Baslund, B., Gregers, J. & Nielsen, Claus Henrik, 1 Apr 2008, In: Rheumatology. 47, 4, p. 451-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Application of new therapies in Graves' disease and thyroid-associated ophthalmopathy: animal models and translation to human clinical trialsTumor necrosis factor-alpha binding capacity and anti-infliximab antibodies measured by fluid-phase radioimmunoassays as predictors of clinical efficacy of infliximab in Crohn's disease
Banga, J. P., Gilbert, J. A., El, F. D., Hegedus, L. & Nielsen, Claus Henrik, 2008, In: Thyroid. 18, 9, p. 973-981 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
B-lymfocytdepletring og andre biologiske behandlingsmuligheder ved Graves' oftalmopatiTumor necrosis factor-alpha binding capacity and anti-infliximab antibodies measured by fluid-phase radioimmunoassays as predictors of clinical efficacy of infliximab in Crohn's disease
El, F. D., Hegedus, L. & Nielsen, Claus Henrik, 2008, In: Ugeskrift for læger. 170, 24, p. 2128-2130 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reduced folate carrier polymorphism determines methotrexate uptake by B cells and CD4+ T cellsTumor necrosis factor-alpha binding capacity and anti-infliximab antibodies measured by fluid-phase radioimmunoassays as predictors of clinical efficacy of infliximab in Crohn's disease
Baslund, B., Gregers, J. & Nielsen, Claus Henrik, 2008, In: Rheumatology.(Oxford). 47, 4, p. 451-453 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Treatment of Graves' disease with rituximab specifically reduces the production of thyroid stimulating autoantibodies
Fassi, Daniel El , Banga, J. P., Gilbert, J. A., Padoa, C., Hegedüs, L. & Nielsen, Claus Henrik, 2008, In: Clinical Immunology. 130, 3, p. 252-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ulcerative colitis following B lymphocyte depletion with rituximab in a patient with Graves' diseaseTumor necrosis factor-alpha binding capacity and anti-infliximab antibodies measured by fluid-phase radioimmunoassays as predictors of clinical efficacy of infliximab in Crohn's disease
El, F. D., Kjeldsen, J., Clemmensen, O., Hegedus, L. & Nielsen, Claus Henrik, 2008, In: Gut. 57, 5, p. 714-715 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Evidence of intrathyroidal B-lymphocyte depletion after rituximab therapy in a patient with Graves' disease
Fassi, Daniel El , Clemmensen, O., Nielsen, Claus Henrik, Silkiss, R. Z. & Hegedüs, L., 1 Oct 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 10, p. 3762-3 2 p.Research output: Contribution to journal › Journal article › Research
- Published
B-cell depletion with rituximab in the treatment of autoimmune diseases. Graves' ophthalmopathy the latest addition to an expanding family
Nielsen, Claus Henrik, Fassi, Daniel El , Hasselbalch, H. K., Bendtzen, K. & Hegedüs, L., 1 Jul 2007, In: Expert Opinion on Biological Therapy. 7, 7, p. 1061-78 18 p.Research output: Contribution to journal › Journal article › Research
- Published
B lymphocyte depletion with the monoclonal antibody rituximab in Graves' disease: a controlled pilot study
Fassi, Daniel El , Nielsen, Claus Henrik, Bonnema, S. J., Hasselbalch, H. K. & Hegedüs, L., 1 May 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 5, p. 1769-72 4 p.Research output: Contribution to journal › Journal article › Research
- Published
Gene expression profiling in autoimmune diseases: chronic inflammation or disease specific patterns?
Bovin, L. F., Brynskov, J., Hegedüs, L., Jess, T., Nielsen, Claus Henrik & Bendtzen, K., 1 May 2007, In: Autoimmunity. 40, 3, p. 191-201 11 p.Research output: Contribution to journal › Journal article › Research
- Published
Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells
Nielsen, Claus Henrik, Albertsen, L., Bendtzen, K. & Baslund, B., 1 May 2007, In: Clinical and Experimental Immunology. 148, 2, p. 288-95 8 p.Research output: Contribution to journal › Journal article › Research
- Published
Production of interleukin (IL)-5 and IL-10 accompanies T helper cell type 1 (Th1) cytokine responses to a major thyroid self-antigen, thyroglobulin, in health and autoimmune thyroid disease
Nielsen, Claus Henrik, Hegedüs, L., Rieneck, K., Moeller, A. C., Leslie, R. G. Q. & Bendtzen, K., 1 Feb 2007, In: Clinical and Experimental Immunology. 147, 2, p. 287-95 9 p.Research output: Contribution to journal › Journal article › Research
- 2006
- Published
Rituximab (MabThera) til behandling af aktiv reumatoid artritis
Fassi, Daniel El , Nielsen, Claus Henrik & Bendtzen, K., 20 Nov 2006, In: Ugeskrift for Laeger. 168, 47, p. 4079-81 3 p.Research output: Contribution to journal › Journal article › Research
- Published
Increased plasma levels of IL-6 in bacteremic periodontis patients after scaling
Forner, L., Nielsen, Claus Henrik, Bendtzen, K., Larsen, Tove & Holmstrup, Palle, 1 Oct 2006, In: Journal of Clinical Periodontology. 33, 10, p. 724-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Treatment-resistant severe, active Graves' ophthalmopathy successfully treated with B lymphocyte depletion
Fassi, Daniel El , Nielsen, Claus Henrik, Hasselbalch, H. K. & Hegedüs, L., 1 Jul 2006, In: Thyroid. 16, 7, p. 709-10 2 p.Research output: Contribution to journal › Journal article › Research
- Published
Class switch recombination in selective IgA-deficient subjects
Jensen, L. H., Ryder, L. P., Nielsen, L. K., Nielsen, Claus Henrik & Poulsen, Lars K., 1 Jun 2006, In: Clinical and Experimental Immunology. 144, 3, p. 458-66 9 p.Research output: Contribution to journal › Journal article › Research
- Published
Surfactant protein D is proatherogenic in mice
Sorensen, G. L., Madsen, J., Kejling, K., Tornoe, I., Nielsen, O., Townsend, P., Poulain, F., Nielsen, Claus Henrik, Reid, K. B. M., Hawgood, S., Falk, E. & Holmskov, U., 1 Jun 2006, In: American Journal of Physiology: Heart and Circulatory Physiology. 290, 6, p. H2286-94Research output: Contribution to journal › Journal article › Research
- Published
The rationale for B lymphocyte depletion in Graves' disease. Monoclonal anti-CD20 antibody therapy as a novel treatment option
Fassi, Daniel El , Nielsen, Claus Henrik, Hasselbalch, H. K. & Hegedüs, L., 1 May 2006, In: European Journal of Endocrinology. 154, 5, p. 623-32 10 p.Research output: Contribution to journal › Journal article › Research
- Published
Differential effect of conditioning regimens on cytokine responses during allogeneic stem cell transplantation
Andersen, J., Heilmann, C., Jacobsen, N., Nielsen, Claus Henrik, Bendtzen, K. & Müller, K., 1 Apr 2006, In: Bone Marrow Transplantation. 37, 7, p. 635-40 6 p.Research output: Contribution to journal › Journal article › Research
- Published
Immunological characteristics of subjects with asymptomatic skin sensitization to birch and grass pollen
Assing, K., Nielsen, Claus Henrik & Poulsen, Lars K., 1 Mar 2006, In: Clinical and Experimental Allergy. 36, 3, p. 283-92 10 p.Research output: Contribution to journal › Journal article › Research
- Published
Self-reactive CD4+ T cells and B cells in the blood in health and autoimmune disease: increased frequency of thyroglobulin-reactive cells in Graves' disease
Nielsen, Claus Henrik, Moeller, A. C., Hegedüs, L., Bendtzen, K. & Leslie, R. G. Q., 1 Mar 2006, In: Journal of Clinical Immunology. 26, 2, p. 126-37 12 p.Research output: Contribution to journal › Journal article › Research
- Published
GABA(A) receptor function is regulated by lipid bilayer elasticity
Søgaard, R., Werge, T. M., Bertelsen, C., Lundbye, C., Madsen, Kenneth Lindegaard, Nielsen, Claus Henrik & Lundbaek, J. A., 2006, In: Biochemistry. 45, 43, p. 13118-29 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Autoantibodies in autoimmune thyroid disease promote immune complex formation with self antigens and increase B cell and CD4+ T cell proliferation in response to self antigens
Nielsen, Claus Henrik, Hegedüs, L. & Leslie, R. G. Q., 1 Jan 2004, In: European Journal of Immunology. 34, 1, p. 263-72 10 p.Research output: Contribution to journal › Journal article › Research
- Published
The classical and alternative pathways of complement activation play distinct roles in spontaneous C3 fragment deposition and membrane attack complex (MAC) formation on human B lymphocytes
Leslie, R. G. Q. & Nielsen, Claus Henrik, 1 Jan 2004, In: Immunology. 111, 1, p. 86-90 5 p.Research output: Contribution to journal › Journal article › Research
- 2003
- Published
Complement receptors type 1 (CR1, CD35) and 2 (CR2, CD21) cooperate in the binding of hydrolyzed complement factor 3 (C3i) to human B lymphocytes
Leslie, R. G. Q., Prodinger, W. M. & Nielsen, Claus Henrik, 1 Dec 2003, In: European Journal of Immunology. 33, 12, p. 3311-21 11 p.Research output: Contribution to journal › Journal article › Research
- 2002
- Published
Complement's participation in acquired immunity
Nielsen, Claus Henrik & Leslie, R. G. Q., 1 Aug 2002, In: Journal of Leukocyte Biology. 72, 2, p. 249-61 13 p.Research output: Contribution to journal › Journal article › Research
- Published
The role of complement receptors type 1 (CR1, CD35) and 2 (CR2, CD21) in promoting C3 fragment deposition and membrane attack complex formation on normal peripheral human B cells
Nielsen, Claus Henrik, Pedersen, M. L., Marquart, Hanne Vibeke Hansen, Prodinger, W. M. & Leslie, R. G. Q., 1 May 2002, In: European Journal of Immunology. 32, 5, p. 1359-67 9 p.Research output: Contribution to journal › Journal article › Research
- 2001
- Published
CR2-mediated activation of the complement alternative pathway results in formation of membrane attack complexes on human B lymphocytes
Nielsen, Claus Henrik, Marquart, Hanne Vibeke Hansen, Prodinger, W. M. & Leslie, R. G., 1 Dec 2001, In: Immunology. 104, 4, p. 418-22 5 p.Research output: Contribution to journal › Journal article › Research
- Published
Natural autoantibodies and complement promote the uptake of a self antigen, human thyroglobulin, by B cells and the proliferation of thyroglobulin-reactive CD4(+) T cells in healthy individuals
Nielsen, Claus Henrik, Leslie, R. G., Jepsen, B. S., Kazatchkine, M. D., Kaveri, S. V. & Fischer, E., 1 Sep 2001, In: European Journal of Immunology. 31, 9, p. 2660-8 9 p.Research output: Contribution to journal › Journal article › Research
- 2000
- Published
The role of complement in the acquired immune response
Nielsen, Claus Henrik, Fischer, E. M. & Leslie, R. G., 1 May 2000, In: Immunology. 100, 1, p. 4-12 9 p.Research output: Contribution to journal › Journal article › Research
- 1998
- Published
Changes in adhesion molecule expression and oxidative burst activity of granulocytes and monocytes during open-heart surgery with cardiopulmonary bypass compared with abdominal surgery
Toft, P., Nielsen, Claus Henrik, Tønnesen, E. K., Hansen, T. G. & Hokland, M., 1 May 1998, In: European Journal of Anaesthesiology. 15, 3, p. 345-53 9 p.Research output: Contribution to journal › Journal article › Research
- Published
Diminished ability of erythrocytes from patients with systemic lupus erythematosus to limit opsonized immune complex deposition on leukocytes and activation of granulocytes
Nielsen, Claus Henrik, Rasmussen, J. M., Voss, A., Junker, P. & Leslie, R. G., 1 Apr 1998, In: Arthritis & Rheumatism. 41, 4, p. 613-22 10 p.Research output: Contribution to journal › Journal article › Research
- 1997
- Published
The roles of complement receptors type 1 (CR1, CD35) and type 3 (CR3, CD11b/CD18) in the regulation of the immune complex-elicited respiratory burst of polymorphonuclear leukocytes in whole blood
Nielsen, Claus Henrik, Antonsen, S., Matthiesen, S. H. & Leslie, R. G., 1 Nov 1997, In: European Journal of Immunology. 27, 11, p. 2914-9 6 p.Research output: Contribution to journal › Journal article › Research
- Published
Effect of methylprednisolone on the oxidative burst activity, adhesion molecules and clinical outcome following open heart surgery
Toft, P., Christiansen, K., Tønnesen, E. K., Nielsen, Claus Henrik & Lillevang, S., 1 Jan 1997, In: Scandinavian Cardiovascular Journal. 31, 5, p. 283-8 6 p.Research output: Contribution to journal › Journal article › Research
- Published
Expression of adhesion and activation molecules on lymphocytes during open-heart surgery with cardiopulmonary bypass
Toft, P., Tønnesen, E. K., Zülow, I., Nielsen, Claus Henrik & Hokland, M., 1 Jan 1997, In: Scandinavian Cardiovascular Journal. 31, 2, p. 91-5 5 p.Research output: Contribution to journal › Journal article › Research
- Published
The role of complement receptor type 1 (CR1, CD35) in determining the cellular distribution of opsonized immune complexes between whole blood cells: kinetic analysis of the buffering capacity of erythrocytes
Nielsen, Claus Henrik, Matthiesen, S. H., Lyng, I. & Leslie, R. G., 1 Jan 1997, In: Immunology. 90, 1, p. 129-37 9 p.Research output: Contribution to journal › Journal article › Research
- 1995
- Published
Complement receptor expression and activation of the complement cascade on B lymphocytes from patients with systemic lupus erythematosus (SLE)
Marquart, Hanne Vibeke Hansen, Svendsen, A., Rasmussen, J. M., Nielsen, Claus Henrik, Junker, P., Svehag, S. E. & Leslie, R. G., 1 Jul 1995, In: Clinical and Experimental Immunology. 101, 1, p. 60-5 6 p.Research output: Contribution to journal › Journal article › Research
- 1994
- Published
The redistribution of granulocytes following E. coli endotoxin induced sepsis
Toft, P., Lillevang, S. T., Tønnesen, E. K., Nielsen, Claus Henrik & Rasmussen, J. W., 1 Nov 1994, In: Acta Anaesthesiologica Scandinavica. 38, 8, p. 852-7 6 p.Research output: Contribution to journal › Journal article › Research
- Published
Interactions of opsonized immune complexes with whole blood cells: binding to erythrocytes restricts complex uptake by leucocyte populations
Nielsen, Claus Henrik, Svehag, S. E., Marquart, Hanne Vibeke Hansen & Leslie, R. G., 1 Aug 1994, In: Scandinavian Journal of Immunology. 40, 2, p. 228-36 9 p.Research output: Contribution to journal › Journal article › Research
- 1993
- Published
Changes in blood levels of proteinase inhibitors, pregnancy zone protein, steroid carriers and complement factors induced by oral contraceptives
Nielsen, Claus Henrik, Poulsen, H. K., Teisner, B., Thorsen, P., Hau, J. & Westergaard, J. G., 1 Sep 1993, In: European Journal of Obstetrics & Gynecology and Reproductive Biology. 51, 1, p. 63-71 9 p.Research output: Contribution to journal › Journal article › Research
ID: 927479
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Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity
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Komorbiditet ved marginal parodontitis: To sider af samme sag?
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Cholesterol crystals enhance TLR2-and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis
Research output: Contribution to journal › Journal article › Research › peer-review
Published