A matrix of cholesterol crystals, but not cholesterol alone, primes human monocytes/macrophages for excessive endotoxin-induced production of tumor necrosis factor-alpha. Role in atherosclerotic inflammation?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A matrix of cholesterol crystals, but not cholesterol alone, primes human monocytes/macrophages for excessive endotoxin-induced production of tumor necrosis factor-alpha. Role in atherosclerotic inflammation? / Bendtzen, Klaus; Christensen, Ole; Nielsen, Claus Henrik; Holmstrup, Palle.

In: Discovery Medicine, Vol. 17, No. 96, 06.2014, p. 309-12.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bendtzen, K, Christensen, O, Nielsen, CH & Holmstrup, P 2014, 'A matrix of cholesterol crystals, but not cholesterol alone, primes human monocytes/macrophages for excessive endotoxin-induced production of tumor necrosis factor-alpha. Role in atherosclerotic inflammation?', Discovery Medicine, vol. 17, no. 96, pp. 309-12. <http://www.discoverymedicine.com/Klaus-Bendtzen/2014/06/a-matrix-of-cholesterol-crystals-primes-monocytes-macrophages-for-excessive-endotoxin-induced-production-of-tumor-necrosis-factor-alpha-role-in-atherosclerotic-inflammation/>

APA

Bendtzen, K., Christensen, O., Nielsen, C. H., & Holmstrup, P. (2014). A matrix of cholesterol crystals, but not cholesterol alone, primes human monocytes/macrophages for excessive endotoxin-induced production of tumor necrosis factor-alpha. Role in atherosclerotic inflammation? Discovery Medicine, 17(96), 309-12. http://www.discoverymedicine.com/Klaus-Bendtzen/2014/06/a-matrix-of-cholesterol-crystals-primes-monocytes-macrophages-for-excessive-endotoxin-induced-production-of-tumor-necrosis-factor-alpha-role-in-atherosclerotic-inflammation/

Vancouver

Bendtzen K, Christensen O, Nielsen CH, Holmstrup P. A matrix of cholesterol crystals, but not cholesterol alone, primes human monocytes/macrophages for excessive endotoxin-induced production of tumor necrosis factor-alpha. Role in atherosclerotic inflammation? Discovery Medicine. 2014 Jun;17(96):309-12.

Author

Bendtzen, Klaus ; Christensen, Ole ; Nielsen, Claus Henrik ; Holmstrup, Palle. / A matrix of cholesterol crystals, but not cholesterol alone, primes human monocytes/macrophages for excessive endotoxin-induced production of tumor necrosis factor-alpha. Role in atherosclerotic inflammation?. In: Discovery Medicine. 2014 ; Vol. 17, No. 96. pp. 309-12.

Bibtex

@article{28be0ef8146842d3bf905c538ace2ad1,
title = "A matrix of cholesterol crystals, but not cholesterol alone, primes human monocytes/macrophages for excessive endotoxin-induced production of tumor necrosis factor-alpha. Role in atherosclerotic inflammation?",
abstract = "When exposed to small amounts of bacterial endotoxin, matrices of cholesterol crystals, but not cholesterol itself, primed human monocytes/macrophages to a highly augmented (>10-fold) production of inflammatory tumor necrosis factor-α. Priming also sensitized the cells, as 10- to 100-fold lower levels of endotoxin were needed for TNF-α production equivalent to that of unprimed cells. The pro-inflammatory effect was selective as endotoxin-induced production of other pro-inflammatory cytokines was unaffected while production of anti-inflammatory interleukin-10 was diminished. These findings suggest that cholesterol matrix formation may play a pathogenic role in atherosclerotic inflammation, and they indicate a mechanism by which bacteria and/or bacterial products may play a role in processes leading to arteriosclerosis.",
author = "Klaus Bendtzen and Ole Christensen and Nielsen, {Claus Henrik} and Palle Holmstrup",
year = "2014",
month = jun,
language = "English",
volume = "17",
pages = "309--12",
journal = "Discovery medicine",
issn = "1539-6509",
publisher = "Solariz, Inc.",
number = "96",

}

RIS

TY - JOUR

T1 - A matrix of cholesterol crystals, but not cholesterol alone, primes human monocytes/macrophages for excessive endotoxin-induced production of tumor necrosis factor-alpha. Role in atherosclerotic inflammation?

AU - Bendtzen, Klaus

AU - Christensen, Ole

AU - Nielsen, Claus Henrik

AU - Holmstrup, Palle

PY - 2014/6

Y1 - 2014/6

N2 - When exposed to small amounts of bacterial endotoxin, matrices of cholesterol crystals, but not cholesterol itself, primed human monocytes/macrophages to a highly augmented (>10-fold) production of inflammatory tumor necrosis factor-α. Priming also sensitized the cells, as 10- to 100-fold lower levels of endotoxin were needed for TNF-α production equivalent to that of unprimed cells. The pro-inflammatory effect was selective as endotoxin-induced production of other pro-inflammatory cytokines was unaffected while production of anti-inflammatory interleukin-10 was diminished. These findings suggest that cholesterol matrix formation may play a pathogenic role in atherosclerotic inflammation, and they indicate a mechanism by which bacteria and/or bacterial products may play a role in processes leading to arteriosclerosis.

AB - When exposed to small amounts of bacterial endotoxin, matrices of cholesterol crystals, but not cholesterol itself, primed human monocytes/macrophages to a highly augmented (>10-fold) production of inflammatory tumor necrosis factor-α. Priming also sensitized the cells, as 10- to 100-fold lower levels of endotoxin were needed for TNF-α production equivalent to that of unprimed cells. The pro-inflammatory effect was selective as endotoxin-induced production of other pro-inflammatory cytokines was unaffected while production of anti-inflammatory interleukin-10 was diminished. These findings suggest that cholesterol matrix formation may play a pathogenic role in atherosclerotic inflammation, and they indicate a mechanism by which bacteria and/or bacterial products may play a role in processes leading to arteriosclerosis.

M3 - Journal article

C2 - 24979250

VL - 17

SP - 309

EP - 312

JO - Discovery medicine

JF - Discovery medicine

SN - 1539-6509

IS - 96

ER -

ID: 120073699