TY - JOUR

T1 - Characteristics of patients with COVID-19 pneumonia at Hvidovre Hospital, March-April 2020

AU - Israelsen, Simone Bastrup

AU - Kristiansen, Klaus Tjelle

AU - Hindsberger, Bettina

AU - Ulrik, Charlotte Suppli

AU - Andersen, Ove

AU - Jensen, Magnus

AU - Andersen, Sten

AU - Rasmussen, Christian

AU - Jørgensen, Henrik L

AU - Østergaard, Christian

AU - Lindhardt, Bjarne Ørskov

AU - Kronborg, Gitte

AU - Benfield, Thomas

N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

PY - 2020/5/15

Y1 - 2020/5/15

N2 - INTRODUCTION: The first case of coronavirus disease 2019 (COVID-19) disease caused by severe acute respiratory syndrome coronavirus-2 occurred in Denmark on 27 February 2020. On 10 March, the first case of COVID-19 pneumonia was admitted to Hvidovre Hospital.METHODS: Retrospective case review of individuals 18 years or older who were admitted consecutively to Hvidovre Hospital from 10 March through 23 April 2020.RESULTS: A total of 175 individuals were admitted with COVID-19 pneumonia. The median age was 71 years, 48.6% were male and 71% had at least one co-morbidity. The most commonly presenting symptoms were dyspnoea, dry cough, and fever. The majority of patients had lymphopenia, elevated liver function tests and C-reactive protein. Nearly two in three presented with multilobar infiltration by chest X-ray. Respiratory failure leading to invasive mechanical ventilation developed in 27 patients (15.4%). By 20 April, 23 of 175 (13.1%) patients remained hospitalised, 43 (24.6%) had died and 109 (62.3%) had been discharged.CONCLUSIONS: The manifestations of COVID-19 at presentation were similar to those seen in other reports. Our population was older, slightly overrepresented by women and had a high level of co-morbidity. COVID-19 admittance was associated with frequent need of intensive care and mechanical ventilation that was associated with a very high mortality.FUNDING: none.TRIAL REGISTRATION: not relevant.

AB - INTRODUCTION: The first case of coronavirus disease 2019 (COVID-19) disease caused by severe acute respiratory syndrome coronavirus-2 occurred in Denmark on 27 February 2020. On 10 March, the first case of COVID-19 pneumonia was admitted to Hvidovre Hospital.METHODS: Retrospective case review of individuals 18 years or older who were admitted consecutively to Hvidovre Hospital from 10 March through 23 April 2020.RESULTS: A total of 175 individuals were admitted with COVID-19 pneumonia. The median age was 71 years, 48.6% were male and 71% had at least one co-morbidity. The most commonly presenting symptoms were dyspnoea, dry cough, and fever. The majority of patients had lymphopenia, elevated liver function tests and C-reactive protein. Nearly two in three presented with multilobar infiltration by chest X-ray. Respiratory failure leading to invasive mechanical ventilation developed in 27 patients (15.4%). By 20 April, 23 of 175 (13.1%) patients remained hospitalised, 43 (24.6%) had died and 109 (62.3%) had been discharged.CONCLUSIONS: The manifestations of COVID-19 at presentation were similar to those seen in other reports. Our population was older, slightly overrepresented by women and had a high level of co-morbidity. COVID-19 admittance was associated with frequent need of intensive care and mechanical ventilation that was associated with a very high mortality.FUNDING: none.TRIAL REGISTRATION: not relevant.

KW - Aged

KW - Aged, 80 and over

KW - Betacoronavirus

KW - Coronavirus Infections/complications

KW - Denmark

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Pandemics

KW - Pneumonia, Viral/complications

KW - Radiography, Thoracic

KW - Respiration, Artificial

KW - Respiratory Insufficiency/etiology

KW - Retrospective Studies

M3 - Journal article

C2 - 32448405

VL - 67

JO - Danish Medical Journal

JF - Danish Medical Journal

SN - 2245-1919

IS - 6

M1 - A05200313

ER -