Effect of a chlorhexidine/thymol and a fluoride varnish on caries development in erupting permanent molars: a comparative study
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Effect of a chlorhexidine/thymol and a fluoride varnish on caries development in erupting permanent molars : a comparative study. / Flamee, S; Gizani, S; Caroni, C; Papagiannoulis, L; Twetman, S.
In: European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, Vol. 16, No. 6, 12.2015, p. 449-54.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of a chlorhexidine/thymol and a fluoride varnish on caries development in erupting permanent molars
T2 - a comparative study
AU - Flamee, S
AU - Gizani, S
AU - Caroni, C
AU - Papagiannoulis, L
AU - Twetman, S
PY - 2015/12
Y1 - 2015/12
N2 - AIM: To compare the caries preventive effect of a chlorhexidine/thymol-containing antibacterial varnish with a fluoride varnish when topically applied during the eruption of permanent molars.METHODS: The study group consisted of 189 patients, 5-14 years of age, with one 1st or 2nd permanent molar in the process of eruption. After stratification for type of molar and stage of eruption, the patients were randomised to either quarterly topical applications with an antibacterial varnish (Cervitec(®) Plus; CV group) or biannual applications with a fluoride varnish plus biannual treatments with placebo varnish (Fluor Protector; FV group). The duration of the study was 2 years. The primary endpoint was caries incidence (initial and cavitated) in the erupting molars and the secondary outcome was salivary mutans streptococci (MS) counts.RESULTS: The groups were balanced with respect to socio-economy, oral hygiene, dietary habits and caries experience at baseline. The dropout rate was 11.6 %. The caries incidence was low (< 10 %) in both groups and there was no significant difference between the CV and FV groups with respect to occlusal caries development in the erupting molars (relative risk 1.08, 95 % CI 0.94-1.25). Significantly lower levels of salivary MS were disclosed in the CV group at the end of the study (p < 0.05).CONCLUSIONS: No difference in occlusal caries development in young permanent molars was displayed after topical applications of either a chlorhexidine/thymol varnish or a fluoride varnish during tooth eruption.
AB - AIM: To compare the caries preventive effect of a chlorhexidine/thymol-containing antibacterial varnish with a fluoride varnish when topically applied during the eruption of permanent molars.METHODS: The study group consisted of 189 patients, 5-14 years of age, with one 1st or 2nd permanent molar in the process of eruption. After stratification for type of molar and stage of eruption, the patients were randomised to either quarterly topical applications with an antibacterial varnish (Cervitec(®) Plus; CV group) or biannual applications with a fluoride varnish plus biannual treatments with placebo varnish (Fluor Protector; FV group). The duration of the study was 2 years. The primary endpoint was caries incidence (initial and cavitated) in the erupting molars and the secondary outcome was salivary mutans streptococci (MS) counts.RESULTS: The groups were balanced with respect to socio-economy, oral hygiene, dietary habits and caries experience at baseline. The dropout rate was 11.6 %. The caries incidence was low (< 10 %) in both groups and there was no significant difference between the CV and FV groups with respect to occlusal caries development in the erupting molars (relative risk 1.08, 95 % CI 0.94-1.25). Significantly lower levels of salivary MS were disclosed in the CV group at the end of the study (p < 0.05).CONCLUSIONS: No difference in occlusal caries development in young permanent molars was displayed after topical applications of either a chlorhexidine/thymol varnish or a fluoride varnish during tooth eruption.
KW - Adolescent
KW - Anti-Infective Agents, Local
KW - Bacterial Load
KW - Cariostatic Agents
KW - Child
KW - Child, Preschool
KW - Chlorhexidine
KW - DMF Index
KW - Dental Caries
KW - Dental Plaque
KW - Drug Combinations
KW - Fluorides, Topical
KW - Food Habits
KW - Humans
KW - Molar
KW - Oral Hygiene
KW - Polyurethanes
KW - Saliva
KW - Silanes
KW - Single-Blind Method
KW - Social Class
KW - Streptococcus mutans
KW - Thymol
KW - Tooth Eruption
U2 - 10.1007/s40368-015-0192-x
DO - 10.1007/s40368-015-0192-x
M3 - Journal article
C2 - 26059497
VL - 16
SP - 449
EP - 454
JO - European archives of paediatric dentistry
JF - European archives of paediatric dentistry
SN - 1818-6300
IS - 6
ER -
ID: 156560919