Effect of chewing gums containing the probiotic bacterium Lactobacillus reuteri on oral malodour
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Effect of chewing gums containing the probiotic bacterium Lactobacillus reuteri on oral malodour. / Keller, Mette K; Bardow, Allan; Jensdottir, Thorbjörg; Lykkeaa, Joan; Twetman, Svante.
In: Acta Odontologica Scandinavica, Vol. 70, No. 3, 2012, p. 246-50.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of chewing gums containing the probiotic bacterium Lactobacillus reuteri on oral malodour
AU - Keller, Mette K
AU - Bardow, Allan
AU - Jensdottir, Thorbjörg
AU - Lykkeaa, Joan
AU - Twetman, Svante
PY - 2012
Y1 - 2012
N2 - OBJECTIVE: To evaluate the effect of chewing gums containing probiotic bacteria on oral malodour. The null hypothesis was that no difference would be displayed compared with placebo gums.MATERIALS AND METHODS: Twenty-five healthy young adults with self-reported malodorous morning breath completed this randomized double-blind placebo-controlled cross-over trial. The design included run-in and wash-out periods interspersed by two intervention periods of 14 days each. The subjects were instructed to chew one gum in the morning and one in the evening containing either two strains of probiotic lactobacilli (L. reuteri DSM 17938 and L. reuteri ATCC PTA 5289) or placebo. The outcome measures were (i) organoleptic scores (0-5) by a certified test panel, (ii) concentration of volatile sulphur compounds (VSC) measured with a Halimeter and (iii) concentration of VSC after a cysteine rinse. Registrations were made at baseline and after each intervention period. Differences between the groups were assessed by non-parametric paired statistics and chi-square test.RESULTS: The median organoleptic score was similar (score 2) in both groups at baseline. After 14 days of treatment, the organoleptic scores were significantly lower in the probiotic group compared with the placebo group (p < 0.05). Assessments of the VSC levels displayed no significant differences between the groups, either before or after rinsing with L-cysteine. No adverse effects were registered.CONCLUSION: The results demonstrated that probiotic chewing gums may have some beneficial effect on oral malodour assessed by organoleptic scores. The results indicate that the probiotic gum may affect bacteria that produce malodourous compounds other than VSCs.
AB - OBJECTIVE: To evaluate the effect of chewing gums containing probiotic bacteria on oral malodour. The null hypothesis was that no difference would be displayed compared with placebo gums.MATERIALS AND METHODS: Twenty-five healthy young adults with self-reported malodorous morning breath completed this randomized double-blind placebo-controlled cross-over trial. The design included run-in and wash-out periods interspersed by two intervention periods of 14 days each. The subjects were instructed to chew one gum in the morning and one in the evening containing either two strains of probiotic lactobacilli (L. reuteri DSM 17938 and L. reuteri ATCC PTA 5289) or placebo. The outcome measures were (i) organoleptic scores (0-5) by a certified test panel, (ii) concentration of volatile sulphur compounds (VSC) measured with a Halimeter and (iii) concentration of VSC after a cysteine rinse. Registrations were made at baseline and after each intervention period. Differences between the groups were assessed by non-parametric paired statistics and chi-square test.RESULTS: The median organoleptic score was similar (score 2) in both groups at baseline. After 14 days of treatment, the organoleptic scores were significantly lower in the probiotic group compared with the placebo group (p < 0.05). Assessments of the VSC levels displayed no significant differences between the groups, either before or after rinsing with L-cysteine. No adverse effects were registered.CONCLUSION: The results demonstrated that probiotic chewing gums may have some beneficial effect on oral malodour assessed by organoleptic scores. The results indicate that the probiotic gum may affect bacteria that produce malodourous compounds other than VSCs.
KW - Adult
KW - Chewing Gum
KW - Double-Blind Method
KW - Female
KW - Halitosis
KW - Humans
KW - Lactobacillus reuteri
KW - Male
KW - Mouth
KW - Probiotics
KW - Reference Values
KW - Sulfur Compounds
KW - Treatment Outcome
KW - Young Adult
U2 - 10.3109/00016357.2011.640281
DO - 10.3109/00016357.2011.640281
M3 - Journal article
C2 - 22182258
VL - 70
SP - 246
EP - 250
JO - Acta Odontologica Scandinavica
JF - Acta Odontologica Scandinavica
SN - 0001-6357
IS - 3
ER -
ID: 34336070