Effect of Probiotic Bacteria on Oral Candida in Frail Elderly
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Effect of Probiotic Bacteria on Oral Candida in Frail Elderly. / Kraft-Bodi, E; Jørgensen, M R; Keller, M K; Kragelund, Camilla; Twetman, S.
In: Journal of Dental Research, Vol. 94, No. 9 Suppl, 09.2015, p. 181S-6S.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of Probiotic Bacteria on Oral Candida in Frail Elderly
AU - Kraft-Bodi, E
AU - Jørgensen, M R
AU - Keller, M K
AU - Kragelund, Camilla
AU - Twetman, S
N1 - © International & American Associations for Dental Research.
PY - 2015/9
Y1 - 2015/9
N2 - The aim of this study was to investigate the effect of a daily intake of probiotic lactobacilli on the prevalence and counts of oral Candida in frail elderly patients living in nursing homes. The study had a double-blind randomized placebo-controlled design with 2 parallel arms. The study group consisted of 215 older adults (range, 60 to 102 y) who were enrolled after informed consent. After baseline examination and randomization, the subjects were given 1 lozenge containing 2 strains of the probiotic bacterium Lactobacillus reuteri (DSM 17938 and ATCC PTA 5289) or placebo twice daily (morning and evening). The intervention period was 12 wk, and saliva and plaque samples were collected at baseline and follow-up. The primary end point was prevalence of high Candida counts assessed from chairside tests. Secondary end points were levels of dental plaque and gingival inflammation. The groups were balanced at baseline. The attrition rate to follow-up was 19%. There was a statistically significant reduction in the prevalence of high Candida counts in the probiotic group but not in the placebo group, and the difference was statistically significant in both saliva and plaque (P < 0.05). No significant differences between the groups were noted concerning the levels of supragingival plaque or bleeding on probing. Thus, daily use of probiotic lozenges may reduce the prevalence of high oral Candida counts in frail elderly nursing homes residents (ClinicalTrials.gov NCT02391532).
AB - The aim of this study was to investigate the effect of a daily intake of probiotic lactobacilli on the prevalence and counts of oral Candida in frail elderly patients living in nursing homes. The study had a double-blind randomized placebo-controlled design with 2 parallel arms. The study group consisted of 215 older adults (range, 60 to 102 y) who were enrolled after informed consent. After baseline examination and randomization, the subjects were given 1 lozenge containing 2 strains of the probiotic bacterium Lactobacillus reuteri (DSM 17938 and ATCC PTA 5289) or placebo twice daily (morning and evening). The intervention period was 12 wk, and saliva and plaque samples were collected at baseline and follow-up. The primary end point was prevalence of high Candida counts assessed from chairside tests. Secondary end points were levels of dental plaque and gingival inflammation. The groups were balanced at baseline. The attrition rate to follow-up was 19%. There was a statistically significant reduction in the prevalence of high Candida counts in the probiotic group but not in the placebo group, and the difference was statistically significant in both saliva and plaque (P < 0.05). No significant differences between the groups were noted concerning the levels of supragingival plaque or bleeding on probing. Thus, daily use of probiotic lozenges may reduce the prevalence of high oral Candida counts in frail elderly nursing homes residents (ClinicalTrials.gov NCT02391532).
KW - Aged
KW - Aged, 80 and over
KW - Candida albicans
KW - Colony Count, Microbial
KW - Dental Plaque
KW - Double-Blind Method
KW - Female
KW - Follow-Up Studies
KW - Frail Elderly
KW - Gingivitis
KW - Homes for the Aged
KW - Humans
KW - Lactobacillus reuteri
KW - Male
KW - Microbial Interactions
KW - Middle Aged
KW - Mouth
KW - Nursing Homes
KW - Oral Hygiene
KW - Placebos
KW - Probiotics
KW - Saliva
U2 - 10.1177/0022034515595950
DO - 10.1177/0022034515595950
M3 - Journal article
C2 - 26202995
VL - 94
SP - 181S-6S
JO - Journal of Dental Research
JF - Journal of Dental Research
SN - 0022-0345
IS - 9 Suppl
ER -
ID: 156560467