Increased plasma levels of IL-6 in bacteremic periodontis patients after scaling
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Increased plasma levels of IL-6 in bacteremic periodontis patients after scaling. / Forner, Lone; Nielsen, Claus Henrik; Bendtzen, Klaus; Larsen, Tove; Holmstrup, Palle.
In: Journal of Clinical Periodontology, Vol. 33, No. 10, 01.10.2006, p. 724-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Increased plasma levels of IL-6 in bacteremic periodontis patients after scaling
AU - Forner, Lone
AU - Nielsen, Claus Henrik
AU - Bendtzen, Klaus
AU - Larsen, Tove
AU - Holmstrup, Palle
PY - 2006/10/1
Y1 - 2006/10/1
N2 - Bacteremia frequently occurs after dental treatment. Periodontal inflammation may influence the incidence, magnitude and duration of bacteremia. The presence of circulating oral bacteria or bacterial components may induce cytokine synthesis in blood cells, which may contribute to the development or exacerbation of atherosclerosis. The present study tested the hypothesis that bacteremia occurring after scaling in periodontitis patients results in altered plasma levels of cytokines. Twenty periodontitis patients were subjected to scaling. Blood samples at baseline and at 0.5, 10 and 30 minutes postscaling were examined for bacteremia whereas baseline and eight-hour postscaling blood samples were examined for the levels of IL-1beta, TNF-alpha, IL-6, IL-8, IL-10 and IL-12p70. IL-6 levels were significantly increased eight hours after scaling, while IL-8 was significantly decreased. No systematic changes occurred in the levels of IL-1beta, TNF-alpha, IL-10 and IL-2p70. IL-6 levels may be increased while IL-8 may be decreased due to scaling, which may have implications for general health.
AB - Bacteremia frequently occurs after dental treatment. Periodontal inflammation may influence the incidence, magnitude and duration of bacteremia. The presence of circulating oral bacteria or bacterial components may induce cytokine synthesis in blood cells, which may contribute to the development or exacerbation of atherosclerosis. The present study tested the hypothesis that bacteremia occurring after scaling in periodontitis patients results in altered plasma levels of cytokines. Twenty periodontitis patients were subjected to scaling. Blood samples at baseline and at 0.5, 10 and 30 minutes postscaling were examined for bacteremia whereas baseline and eight-hour postscaling blood samples were examined for the levels of IL-1beta, TNF-alpha, IL-6, IL-8, IL-10 and IL-12p70. IL-6 levels were significantly increased eight hours after scaling, while IL-8 was significantly decreased. No systematic changes occurred in the levels of IL-1beta, TNF-alpha, IL-10 and IL-2p70. IL-6 levels may be increased while IL-8 may be decreased due to scaling, which may have implications for general health.
KW - Adult
KW - Bacteremia
KW - Bacteroidaceae Infections
KW - Dental Plaque Index
KW - Dental Scaling
KW - Female
KW - Follow-Up Studies
KW - Gingival Hemorrhage
KW - Humans
KW - Interleukin-10
KW - Interleukin-12
KW - Interleukin-6
KW - Interleukin-8
KW - Male
KW - Middle Aged
KW - Periodontal Attachment Loss
KW - Periodontal Index
KW - Periodontal Pocket
KW - Periodontitis
KW - Prevotella
KW - Streptococcal Infections
KW - Streptococcus
KW - Time Factors
KW - Tumor Necrosis Factor-alpha
U2 - 10.1111/j.1600-051X.2006.00964.x
DO - 10.1111/j.1600-051X.2006.00964.x
M3 - Journal article
C2 - 16901299
VL - 33
SP - 724
EP - 729
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
SN - 0303-6979
IS - 10
ER -
ID: 34102961