Infection with human H1N1 influenza virus affects the expression of sialic acids of metaplastic mucous cells in the ferret airways
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Glycans terminating in sialic acids serve as receptors for influenza viruses. In this study ferrets were infected with influenza virus A/New Caledonia/20/99, and the in situ localization of sialic acids linked a2-3 and a2-6 in the airways was investigated in infected and non-infected animals by use of sialic acid detecting lectins and a monoclonal antibody towards the Sialyl-Tn antigen. The goblet cells in the bronchi from non-infected ferrets expressed Sialyla2-6Gal glycans, while the seromucinous glands in the submucosa expressed Sialyla2-3Gal glycans. In the infected animals, the surface epithelial cells in some bronchi showed metaplasia and expressed the Sialyl-Tn antigen: Sialyla2-6GalNAc-O-Thr/Ser. The submucosal tracheal glands in these animals showed increased expression of both Sialyla2-3 and Sialyla2-6 epitopes.
Original language | English |
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Journal | Virus Research |
Volume | 144 |
Issue number | 1-2 |
Pages (from-to) | 225-232 |
Number of pages | 8 |
ISSN | 0168-1702 |
DOIs | |
Publication status | Published - 2009 |
ID: 13924829