Infiltrating/sealing proximal caries lesions: a 3-year randomized clinical trial
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Infiltrating/sealing proximal caries lesions : a 3-year randomized clinical trial. / Martignon, S; Ekstrand, K R; Gomez, J; Lara, J S; Cortes, A.
In: The Chinese Journal of Dental Research, Vol. 91, No. 3, 2012, p. 288-92.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Infiltrating/sealing proximal caries lesions
T2 - a 3-year randomized clinical trial
AU - Martignon, S
AU - Ekstrand, K R
AU - Gomez, J
AU - Lara, J S
AU - Cortes, A
PY - 2012
Y1 - 2012
N2 - This randomized split-mouth controlled clinical trial aimed at assessing the therapeutic effects of infiltration vs. sealing for controlling caries progression on proximal surfaces. Out of 90 adult students/patients assessed at university clinics and agreeing to participate, 39, each with 3 proximal lesions identified radiographically around the enamel-dentin junction to the outer third of the dentin, were included. Lesions were randomly allocated for treatment to test-A (Infiltration: ICON-pre-product; DMG), test-B (Sealing: Prime-Bond-NT; Dentsply), or control-C (Placebo). Primary outcome after 1, 2, and 3 yrs of radiographically observed lesion progression was assessed by an independent examiner blinded to groups, using pair-wise and digital-subtraction readings. No adverse events occurred. In 37 participants assessed after 3 yrs, 10 lesions (A-4; B-2; C-4) progressed deep into dentin and needed operative treatment. The 3-year therapeutic effect, based on pair-wise radiographic readings between infiltration and placebo, was 37.8% (95% CI: 20.5-55.2%) and that between sealing and placebo was 29.7% (95% CI: 20.2-35.0%). One-year follow-up digital-subtraction readings showed significant differences in lesion progression between infiltration and placebo (P = 0.0012) and between sealing and placebo (P = 0.0269). The study showed that infiltration and sealing are significantly better than placebo treatment for controlling caries progression on proximal lesions. No significant difference was seen between infiltration and sealing (ClinicalTrials.gov number NCT01417832).
AB - This randomized split-mouth controlled clinical trial aimed at assessing the therapeutic effects of infiltration vs. sealing for controlling caries progression on proximal surfaces. Out of 90 adult students/patients assessed at university clinics and agreeing to participate, 39, each with 3 proximal lesions identified radiographically around the enamel-dentin junction to the outer third of the dentin, were included. Lesions were randomly allocated for treatment to test-A (Infiltration: ICON-pre-product; DMG), test-B (Sealing: Prime-Bond-NT; Dentsply), or control-C (Placebo). Primary outcome after 1, 2, and 3 yrs of radiographically observed lesion progression was assessed by an independent examiner blinded to groups, using pair-wise and digital-subtraction readings. No adverse events occurred. In 37 participants assessed after 3 yrs, 10 lesions (A-4; B-2; C-4) progressed deep into dentin and needed operative treatment. The 3-year therapeutic effect, based on pair-wise radiographic readings between infiltration and placebo, was 37.8% (95% CI: 20.5-55.2%) and that between sealing and placebo was 29.7% (95% CI: 20.2-35.0%). One-year follow-up digital-subtraction readings showed significant differences in lesion progression between infiltration and placebo (P = 0.0012) and between sealing and placebo (P = 0.0269). The study showed that infiltration and sealing are significantly better than placebo treatment for controlling caries progression on proximal lesions. No significant difference was seen between infiltration and sealing (ClinicalTrials.gov number NCT01417832).
KW - Adolescent
KW - Adult
KW - Cariostatic Agents
KW - Chi-Square Distribution
KW - DMF Index
KW - Dental Caries
KW - Female
KW - Humans
KW - Male
KW - Pit and Fissure Sealants
KW - Radiography, Bitewing
KW - Single-Blind Method
KW - Statistics, Nonparametric
KW - Subtraction Technique
KW - Young Adult
U2 - 10.1177/0022034511435328
DO - 10.1177/0022034511435328
M3 - Journal article
C2 - 22257664
VL - 91
SP - 288
EP - 292
JO - The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)
JF - The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)
SN - 1462-6446
IS - 3
ER -
ID: 38479780