Premalignant and malignant oral lesions are associated with changes in the glycosylation pattern of carbohydrates related to ABH blood group antigens
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Premalignant and malignant oral lesions are associated with changes in the glycosylation pattern of carbohydrates related to ABH blood group antigens. / Dabelsteen, Erik; Clausen, H; Holmstrup, P; Reibel, J.
In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 96, No. 9, 09.1988, p. 813-819.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Premalignant and malignant oral lesions are associated with changes in the glycosylation pattern of carbohydrates related to ABH blood group antigens
AU - Dabelsteen, Erik
AU - Clausen, H
AU - Holmstrup, P
AU - Reibel, J
PY - 1988/9
Y1 - 1988/9
N2 - The distribution of carbohydrate structures related to the ABO(H) blood group antigen system was studied in biopsies from eight squamous cell carcinomas, and eight erythroplakias with epithelial dysplasia. Twenty oral lesions without histological evidence of malignancy (13 lichen planus lesions and 7 homogeneous leukoplakias) were also examined. The distribution of Lex, Ley, H type 2 chain, and N-acetyllactosamine, all type 2 chain carbohydrate structures, was investigated by immunohistological staining using monoclonal antibodies with selected specificity. The histological pattern of expression of these antigens in the benign lesions was similar to that of normal oral mucosa, i.e. expression of: N-acetyllactosamine on basal cells, H antigen on parabasal cells, and Lex and Ley on spinous cells. However, lesions with epithelial dysplasia showed H antigen on all spinous cells, and often also on basal cells, with expression of Lex and Ley restricted to the most superficial part of the epithelium above the H-positive cell layers. In carcinomas most cells were negative for H antigen but were positive for Ley and Lex in 5 out of 8 cases.
AB - The distribution of carbohydrate structures related to the ABO(H) blood group antigen system was studied in biopsies from eight squamous cell carcinomas, and eight erythroplakias with epithelial dysplasia. Twenty oral lesions without histological evidence of malignancy (13 lichen planus lesions and 7 homogeneous leukoplakias) were also examined. The distribution of Lex, Ley, H type 2 chain, and N-acetyllactosamine, all type 2 chain carbohydrate structures, was investigated by immunohistological staining using monoclonal antibodies with selected specificity. The histological pattern of expression of these antigens in the benign lesions was similar to that of normal oral mucosa, i.e. expression of: N-acetyllactosamine on basal cells, H antigen on parabasal cells, and Lex and Ley on spinous cells. However, lesions with epithelial dysplasia showed H antigen on all spinous cells, and often also on basal cells, with expression of Lex and Ley restricted to the most superficial part of the epithelium above the H-positive cell layers. In carcinomas most cells were negative for H antigen but were positive for Ley and Lex in 5 out of 8 cases.
KW - ABO Blood-Group System
KW - Antibodies, Monoclonal
KW - Antigens, Neoplasm
KW - Carcinoma, Squamous Cell
KW - Epithelium
KW - Fluorescent Antibody Technique
KW - Glycoconjugates
KW - Glycosylation
KW - Humans
KW - Leukoplakia
KW - Lewis Blood-Group System
KW - Lichen Planus
KW - Mouth Mucosa
KW - Mouth Neoplasms
KW - Precancerous Conditions
U2 - 10.1111/j.1699-0463.1988.tb00948.x
DO - 10.1111/j.1699-0463.1988.tb00948.x
M3 - Journal article
C2 - 3048339
VL - 96
SP - 813
EP - 819
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 9
ER -
ID: 119595530