TY - JOUR

T1 - Probiotic supplements and postoperative complications after tooth extractions and third molar surgery

T2 - a systematic review

AU - Jørgensen, Mette R.

AU - Abrahamsson, Peter

AU - Wälivaara, Dan Åke

AU - Twetman, Svante

N1 - Publisher Copyright: © Minerva Dental and Oral Science.

PY - 2022

Y1 - 2022

N2 - INTRODUCTION: Probiotics have gained considerable attention as intervention for various conditions in dentistry. The purpose of this review is to evaluate the current literature on the efficacy of probiotic supplements for alleviating symptoms after tooth extractions and third molar surgery. EVIDENCEACQUISITION: We searched the PubMed and Google Scholar databases up to October 15, 2021 using pertinent keywords to retrieve relevant literature. Based on abstracts, the authors reviewed the full text papers, extracted key outcome data, and assessed the risk of bias. EVIDENCESYNTHESIS: Four articles based on three RCT's were included of which three allowed compilation. There were no beneficial effects on the occurrence of postoperative infections or alveolitis, but we disclosed a significant trend towards less self-reported pain one week after the tooth extractions (RD -0.22; 95% CI-0.33; -0.11; P<0.05). Findings concerning swelling, discomfort and use of painkillers were inconsistent. CONCLUSIONS: Probiotic supplements may offer clinical benefits within oral surgery, such as alleviating pain after tooth extractions. However, the certainty of these findings was very low due to risk of bias, heterogeneity, and inconsistencies across the studies. Further and larger investigations are required to strengthen the level of evidence.

AB - INTRODUCTION: Probiotics have gained considerable attention as intervention for various conditions in dentistry. The purpose of this review is to evaluate the current literature on the efficacy of probiotic supplements for alleviating symptoms after tooth extractions and third molar surgery. EVIDENCEACQUISITION: We searched the PubMed and Google Scholar databases up to October 15, 2021 using pertinent keywords to retrieve relevant literature. Based on abstracts, the authors reviewed the full text papers, extracted key outcome data, and assessed the risk of bias. EVIDENCESYNTHESIS: Four articles based on three RCT's were included of which three allowed compilation. There were no beneficial effects on the occurrence of postoperative infections or alveolitis, but we disclosed a significant trend towards less self-reported pain one week after the tooth extractions (RD -0.22; 95% CI-0.33; -0.11; P<0.05). Findings concerning swelling, discomfort and use of painkillers were inconsistent. CONCLUSIONS: Probiotic supplements may offer clinical benefits within oral surgery, such as alleviating pain after tooth extractions. However, the certainty of these findings was very low due to risk of bias, heterogeneity, and inconsistencies across the studies. Further and larger investigations are required to strengthen the level of evidence.

KW - Pain, postoperative

KW - Probiotics

KW - Surgery, oral

KW - Surgical wound infection

KW - Tooth extraction

U2 - 10.23736/S2724-6329.22.04661-7

DO - 10.23736/S2724-6329.22.04661-7

M3 - Review

C2 - 35920291

AN - SCOPUS:85135429548

VL - 71

SP - 242

EP - 247

JO - Minerva Dental and Oral Science

JF - Minerva Dental and Oral Science

SN - 2724-6329

IS - 4

ER -