Systematic review and meta-analysis of diagnostic studies of proximal surface caries
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Systematic review and meta-analysis of diagnostic studies of proximal surface caries. / Janjic Rankovic, Mila; Kapor, Svetlana; Khazaei, Yegane; Crispin, Alexander; Schüler, Ina; Krause, Felix; Ekstrand, Kim; Michou, Stavroula; Eggmann, Florin; Lussi, Adrian; Huysmans, Marie-Charlotte; Neuhaus, Klaus; Kühnisch, Jan.
In: Clinical Oral Investigations, Vol. 25, No. 11, 2021, p. 6069-6079.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Systematic review and meta-analysis of diagnostic studies of proximal surface caries
AU - Janjic Rankovic, Mila
AU - Kapor, Svetlana
AU - Khazaei, Yegane
AU - Crispin, Alexander
AU - Schüler, Ina
AU - Krause, Felix
AU - Ekstrand, Kim
AU - Michou, Stavroula
AU - Eggmann, Florin
AU - Lussi, Adrian
AU - Huysmans, Marie-Charlotte
AU - Neuhaus, Klaus
AU - Kühnisch, Jan
N1 - Publisher Copyright: © 2021, The Author(s).
PY - 2021
Y1 - 2021
N2 - Aim: This systematic review and meta-analysis aimed to assess the diagnostic accuracy and reliability of commonly used caries detection methods for proximal caries diagnostics. Visual examination (VE), bitewing radiography (BWR), laser fluorescence (LF), and fibre-optic transillumination (FOTI) were considered in detail. Material and methods: PRISMA guidelines for the reporting of systematic reviews and meta-analyses were applied. The mnemonic PIRDS (problem, index test, reference test, diagnostic and study type) concept was used to guide the literature search. Next, studies that met the inclusion criteria were stepwise selected and evaluated for their quality with a risk of bias (RoB) assessment tool. Studies with low/moderate bias and sufficient reporting were considered for meta-analysis. The pooled sensitivity (SE), specificity (SP), diagnostic odds ratio (DOR), and area under the ROC curve (AUC) were calculated. Results: From 129 studies meeting the selection criteria, 31 in vitro studies and five clinical studies were finally included in the meta-analysis. The AUC values for in vitro VE amounted to 0.84 (caries detection) and 0.85 (dentin caries detection). BWR ranged in vitro from 0.55 to 0.82 (caries detection) and 0.81–0.92 (dentin caries detection). LF showed higher AUC values for overall caries detection (0.91) and dentin caries detection (0.83) than did other methods. Clinical data are limited. Conclusion: The number of diagnostic studies with low/moderate RoB was found to be low and indicates a need for high-quality, well-designed caries diagnostic studies. Clinical relevance: BWR and LF showed good diagnostic performance on proximal surfaces. However, because of the low number of includable clinical studies, these data should be interpreted with caution.
AB - Aim: This systematic review and meta-analysis aimed to assess the diagnostic accuracy and reliability of commonly used caries detection methods for proximal caries diagnostics. Visual examination (VE), bitewing radiography (BWR), laser fluorescence (LF), and fibre-optic transillumination (FOTI) were considered in detail. Material and methods: PRISMA guidelines for the reporting of systematic reviews and meta-analyses were applied. The mnemonic PIRDS (problem, index test, reference test, diagnostic and study type) concept was used to guide the literature search. Next, studies that met the inclusion criteria were stepwise selected and evaluated for their quality with a risk of bias (RoB) assessment tool. Studies with low/moderate bias and sufficient reporting were considered for meta-analysis. The pooled sensitivity (SE), specificity (SP), diagnostic odds ratio (DOR), and area under the ROC curve (AUC) were calculated. Results: From 129 studies meeting the selection criteria, 31 in vitro studies and five clinical studies were finally included in the meta-analysis. The AUC values for in vitro VE amounted to 0.84 (caries detection) and 0.85 (dentin caries detection). BWR ranged in vitro from 0.55 to 0.82 (caries detection) and 0.81–0.92 (dentin caries detection). LF showed higher AUC values for overall caries detection (0.91) and dentin caries detection (0.83) than did other methods. Clinical data are limited. Conclusion: The number of diagnostic studies with low/moderate RoB was found to be low and indicates a need for high-quality, well-designed caries diagnostic studies. Clinical relevance: BWR and LF showed good diagnostic performance on proximal surfaces. However, because of the low number of includable clinical studies, these data should be interpreted with caution.
KW - Approximal caries
KW - Bitewing radiography
KW - Caries detection
KW - Caries diagnostics
KW - Diagnostic accuracy
KW - Diagnostic performance
KW - Fibre-optic transillumination
KW - Interproximal caries
KW - Laser fluorescence measurements
KW - Meta-analysis
KW - Proximal caries
KW - Sensitivity
KW - Specificity
KW - Systematic review
KW - Visual examination
U2 - 10.1007/s00784-021-04113-1
DO - 10.1007/s00784-021-04113-1
M3 - Review
C2 - 34480645
AN - SCOPUS:85114177201
VL - 25
SP - 6069
EP - 6079
JO - Clinical Oral Investigations
JF - Clinical Oral Investigations
SN - 1432-6981
IS - 11
ER -
ID: 280174380