The activity of non-specific esterase in the thyroid epithelial cells of the guinea pig as influenced by various inhibitors and activators: A histochemical study
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The action of various inhibitors and activators upon esterase activity in the thyroid epithelial cells is demonstrated. The agents used were triorthocresylphosphate (TOCP), parachloromercuribenzoate (PCMB), Arsanillic acid, p-nitrophenyl dimethyl carbamate and bis p-nitrophenyl phosphate. TOCP was found to inhibit selectively the activity in the follicle cells proper when alpha naphthyl acetate was used as a substrate. Arsanillic acid (0,001 M) activated the follicle cells proper selectively, but if the concentration was raised to 0,01 M the effect was that of inhibition while the activity in the para-, inter- and intrafollicular cells was unchanged. The results obtained are related to previous biochemical and histochemical observations and the nature of esterases in the thyroid is discussed.
Original language | English |
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Journal | Histochemistry |
Volume | 48 |
Issue number | 1 |
Pages (from-to) | 51-60 |
ISSN | 0301-5564 |
DOIs | |
Publication status | Published - 1976 |
Bibliographical note
Keywords: Acetylesterase; Animals; Carbamates; Chloromercuribenzoates; Esterases; Guinea Pigs; Histocytochemistry; Thyroid Gland; Tritolyl Phosphates
ID: 10026761