The complement system and its role in the pathogenesis of periodontitis: current concepts
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The complement system and its role in the pathogenesis of periodontitis : current concepts. / Damgaard, Christian; Holmstrup, Palle; Van Dyke, Thomas E.; Nielsen, Claus Henrik.
In: Journal of Periodontal Research, Vol. 50, No. 3, 06.2015, p. 283-293.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The complement system and its role in the pathogenesis of periodontitis
T2 - current concepts
AU - Damgaard, Christian
AU - Holmstrup, Palle
AU - Van Dyke, Thomas E.
AU - Nielsen, Claus Henrik
PY - 2015/6
Y1 - 2015/6
N2 - Periodontitis is a highly prevalent inflammatory disease in tooth supporting tissues, induced by bacteria growing in a biofilm on tooth surfaces. Components of the complement system are present in the periodontal tissue and the system is activated in periodontitis. Continuous complement activation and modulation by bacteria within the biofilm in periodontal pockets, however, may enhance local tissue destruction, providing the biofilm with both essential nutrients and space to grow. A more profound understanding of the mechanisms involved in complement-derived tissue degradation may facilitate the development of new treatment concepts for periodontitis. Further studies on the role of complement in periodontitis pathogenesis may also contribute to the understanding of why some individuals fail to resolve periodontitis. Here, we review evidence that links complement to the pathogenesis of periodontitis with an emphasis on interaction of complement with bacteria from periodontitis-associated biofilm.
AB - Periodontitis is a highly prevalent inflammatory disease in tooth supporting tissues, induced by bacteria growing in a biofilm on tooth surfaces. Components of the complement system are present in the periodontal tissue and the system is activated in periodontitis. Continuous complement activation and modulation by bacteria within the biofilm in periodontal pockets, however, may enhance local tissue destruction, providing the biofilm with both essential nutrients and space to grow. A more profound understanding of the mechanisms involved in complement-derived tissue degradation may facilitate the development of new treatment concepts for periodontitis. Further studies on the role of complement in periodontitis pathogenesis may also contribute to the understanding of why some individuals fail to resolve periodontitis. Here, we review evidence that links complement to the pathogenesis of periodontitis with an emphasis on interaction of complement with bacteria from periodontitis-associated biofilm.
U2 - 10.1111/jre.12209
DO - 10.1111/jre.12209
M3 - Review
C2 - 25040158
VL - 50
SP - 283
EP - 293
JO - Journal of Periodontal Research
JF - Journal of Periodontal Research
SN - 0022-3484
IS - 3
ER -
ID: 123267351