The effect of EDTA and metal cations on the 5-bromoindoxyl acetate esterase activity in the thyroid of the guinea pig
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Miscellaneous metal cations and EDTA have been used as activators and inhibitors of esterase activity in the thyroid of the guinea-pig. The results indicate that the 5-bromoiondoxyl acetate esterase in the epithelial cells probably consists of two different A-esterase isoenzymes, one present in group I cells (the para-, intra-, and inter-follicular cells) and the other in group II cells (the follicular cells proper). The first isoenzyme seems to be calcium-dependent whereas the other is activated by various metal ions. Ca2+ + Mn2+ and Ca2+ + Co2+ were found to activate the esterase activity in group I cells. EDTA and Mn2+, on the other hand, activated the esterase activity in group II cells.
Original language | English |
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Journal | Journal of Molecular Histology (Print Edition) |
Volume | 8 |
Issue number | 5 |
Pages (from-to) | 463-70 |
Number of pages | 7 |
ISSN | 1567-2379 |
Publication status | Published - 1976 |
Bibliographical note
Keywords: Animals; Calcium; Cobalt; Edetic Acid; Enzyme Activation; Esterases; Guinea Pigs; Histocytochemistry; Magnesium; Manganese; Staining and Labeling; Thyroid Gland; Zinc
ID: 10026736