The efficacy of combined arginine and probiotics as an add-on to 1450 ppm fluoride toothpaste to prevent and control dental caries in children – A randomized controlled trial
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The efficacy of combined arginine and probiotics as an add-on to 1450 ppm fluoride toothpaste to prevent and control dental caries in children – A randomized controlled trial. / Pørksen, Camilla Juhl; Ekstrand, Kim Rud; Markvart, Merete; Larsen, Tove; Garrido, Luis Eduardo; Bakhshandeh, Azam.
In: Journal of Dentistry, Vol. 137, 104670, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The efficacy of combined arginine and probiotics as an add-on to 1450 ppm fluoride toothpaste to prevent and control dental caries in children – A randomized controlled trial
AU - Pørksen, Camilla Juhl
AU - Ekstrand, Kim Rud
AU - Markvart, Merete
AU - Larsen, Tove
AU - Garrido, Luis Eduardo
AU - Bakhshandeh, Azam
N1 - Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
PY - 2023
Y1 - 2023
N2 - OBJECTIVES: To determine how daily consumption of a lozenge combining arginine and two probiotic strains affects the Relative Risk Reduction (RRR) in children regarding dental caries transitions and lesion activity at tooth surface level during 10-12 months.METHODS: A total of 21,888 tooth surfaces in 288 children were examined. The intervention group (n= 141) received a lozenge containing 2% arginine, Lacticaseibacillus rhamnosus, LGG® (DSM33156), Lactobacillus paracasei subsp. paracasei, L. CASEI 431® (DSM33451). The placebo group (n= 147) received a placebo lozenge. Both groups received 1,450 ppm F - toothpaste. Primary canines, molars, and first permanent molars were examined clinically (ICDAS 0-6) and radiographically (R 0-6) at baseline and follow-up. Sealed, filled, and missing surfaces were included. Caries activity was computed as a sum of each caries lesion's location, color, texture, cavitation, and gingival bleeding. RRRs were computed with cluster effect on surface level. ICH-GCP was followed, including external monitoring. RESULTS: A total of 19,950 surfaces were analyzed after excluding 1,938 tooth surfaces. No statistically significant differences were found between the groups. The RRRs showed less caries progression (13.6%, p= 0.20), more regression (0.3%, p= 0.44), and fewer active caries lesions (15.3%, p= 0.15) in the intervention group.CONCLUSION: Daily consumption of a lozenge combining arginine and probiotics for 10-12 months given to 5-9-years-old children characterized being with low caries risk demonstrated a marked, though not statistically significant RRR for caries progression, regression, and number of active lesions in the intervention group compared to the placebo-group.CLINICALTRIALS: gov (NCT03928587).CLINICAL SIGNIFICANCE: Since all the RRRs were in favor of the intervention group and the PF of combined arginine and probiotics is high (81.6%) compared to fluoride toothpaste (24.9%) and arginine-fluoride toothpaste alone (19.6%) the combined pre-and probiotics approach may be a future additional tool regarding caries prevention and control.
AB - OBJECTIVES: To determine how daily consumption of a lozenge combining arginine and two probiotic strains affects the Relative Risk Reduction (RRR) in children regarding dental caries transitions and lesion activity at tooth surface level during 10-12 months.METHODS: A total of 21,888 tooth surfaces in 288 children were examined. The intervention group (n= 141) received a lozenge containing 2% arginine, Lacticaseibacillus rhamnosus, LGG® (DSM33156), Lactobacillus paracasei subsp. paracasei, L. CASEI 431® (DSM33451). The placebo group (n= 147) received a placebo lozenge. Both groups received 1,450 ppm F - toothpaste. Primary canines, molars, and first permanent molars were examined clinically (ICDAS 0-6) and radiographically (R 0-6) at baseline and follow-up. Sealed, filled, and missing surfaces were included. Caries activity was computed as a sum of each caries lesion's location, color, texture, cavitation, and gingival bleeding. RRRs were computed with cluster effect on surface level. ICH-GCP was followed, including external monitoring. RESULTS: A total of 19,950 surfaces were analyzed after excluding 1,938 tooth surfaces. No statistically significant differences were found between the groups. The RRRs showed less caries progression (13.6%, p= 0.20), more regression (0.3%, p= 0.44), and fewer active caries lesions (15.3%, p= 0.15) in the intervention group.CONCLUSION: Daily consumption of a lozenge combining arginine and probiotics for 10-12 months given to 5-9-years-old children characterized being with low caries risk demonstrated a marked, though not statistically significant RRR for caries progression, regression, and number of active lesions in the intervention group compared to the placebo-group.CLINICALTRIALS: gov (NCT03928587).CLINICAL SIGNIFICANCE: Since all the RRRs were in favor of the intervention group and the PF of combined arginine and probiotics is high (81.6%) compared to fluoride toothpaste (24.9%) and arginine-fluoride toothpaste alone (19.6%) the combined pre-and probiotics approach may be a future additional tool regarding caries prevention and control.
U2 - 10.1016/j.jdent.2023.104670
DO - 10.1016/j.jdent.2023.104670
M3 - Journal article
C2 - 37604396
VL - 137
JO - Journal of Dentistry
JF - Journal of Dentistry
SN - 0300-5712
M1 - 104670
ER -
ID: 363271840