TY - JOUR

T1 - Salivary microbial profiles in 5-year old children with oral clefts

T2 - a comparative study

AU - Sundell, A L

AU - Ullbro, C

AU - Dahlén, G

AU - Marcusson, A

AU - Twetman, S

PY - 2018

Y1 - 2018

N2 - AIM: To compare the salivary microbial profile in children with oral clefts to matched non-cleft controls in a cross-sectional study.METHODS: The cleft group consisted of 80 children aged 5 years and 144 age-matched non-cleft children were recruited as a control group. Stimulated whole saliva samples were collected and analysed with checkerboard DNA-DNA hybridisation using 12 pre-determined bacterial probes. Background data on caries, oral hygiene, dietary habits and fluoride exposure were collected from clinical examinations and questionnaires.RESULTS: Children in the cleft group had a significantly higher prevalence of dental caries but only minor differences in the salivary microbial profile were found. In general, the cleft-children displayed a lower prevalence of common commensal species (e.g. Streptococcus, Fusobacterium) when compared with the non-cleft controls. The differences were statistically significant (p < 0.05) but the clinical significance was unclear.CONCLUSIONS: The profile of the salivary microflora in 5-year-old children with and without oral clefts was basically similar and displayed only marginal differences with respect to commensal bacteria.

AB - AIM: To compare the salivary microbial profile in children with oral clefts to matched non-cleft controls in a cross-sectional study.METHODS: The cleft group consisted of 80 children aged 5 years and 144 age-matched non-cleft children were recruited as a control group. Stimulated whole saliva samples were collected and analysed with checkerboard DNA-DNA hybridisation using 12 pre-determined bacterial probes. Background data on caries, oral hygiene, dietary habits and fluoride exposure were collected from clinical examinations and questionnaires.RESULTS: Children in the cleft group had a significantly higher prevalence of dental caries but only minor differences in the salivary microbial profile were found. In general, the cleft-children displayed a lower prevalence of common commensal species (e.g. Streptococcus, Fusobacterium) when compared with the non-cleft controls. The differences were statistically significant (p < 0.05) but the clinical significance was unclear.CONCLUSIONS: The profile of the salivary microflora in 5-year-old children with and without oral clefts was basically similar and displayed only marginal differences with respect to commensal bacteria.

KW - Child, Preschool

KW - Cleft Lip/complications

KW - Cleft Palate/complications

KW - Cross-Sectional Studies

KW - Dental Caries/epidemiology

KW - Female

KW - Humans

KW - Male

KW - Prevalence

KW - Saliva/microbiology

KW - Surveys and Questionnaires

U2 - 10.1007/s40368-018-0326-z

DO - 10.1007/s40368-018-0326-z

M3 - Journal article

C2 - 29392531

VL - 19

SP - 57

EP - 60

JO - European archives of paediatric dentistry

JF - European archives of paediatric dentistry

SN - 1818-6300

IS - 1

ER -