Salivary microbial profiles in 5-year old children with oral clefts: a comparative study
Research output: Contribution to journal › Journal article › Research › peer-review
AIM: To compare the salivary microbial profile in children with oral clefts to matched non-cleft controls in a cross-sectional study.
METHODS: The cleft group consisted of 80 children aged 5 years and 144 age-matched non-cleft children were recruited as a control group. Stimulated whole saliva samples were collected and analysed with checkerboard DNA-DNA hybridisation using 12 pre-determined bacterial probes. Background data on caries, oral hygiene, dietary habits and fluoride exposure were collected from clinical examinations and questionnaires.
RESULTS: Children in the cleft group had a significantly higher prevalence of dental caries but only minor differences in the salivary microbial profile were found. In general, the cleft-children displayed a lower prevalence of common commensal species (e.g. Streptococcus, Fusobacterium) when compared with the non-cleft controls. The differences were statistically significant (p < 0.05) but the clinical significance was unclear.
CONCLUSIONS: The profile of the salivary microflora in 5-year-old children with and without oral clefts was basically similar and displayed only marginal differences with respect to commensal bacteria.
Original language | English |
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Journal | European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry |
Volume | 19 |
Issue number | 1 |
Pages (from-to) | 57-60 |
Number of pages | 4 |
ISSN | 1818-6300 |
DOIs | |
Publication status | Published - 2018 |
- Child, Preschool, Cleft Lip/complications, Cleft Palate/complications, Cross-Sectional Studies, Dental Caries/epidemiology, Female, Humans, Male, Prevalence, Saliva/microbiology, Surveys and Questionnaires
Research areas
ID: 203775776